Hypofractionation (Radiation) Trial for Multiple Myeloma

Eligibility Criteria

• 1. Signed Written Informed Consent
• * Participants must be able to give self-consent and then sign and date an Institutional Review Board (IRB)/Independent Ethics Committee (IEC)-approved written informed consent in accordance with local regulatory and institutional guidelines. This consent must be obtained before the performance of any protocol-related procedures that are not considered part of normal participant care.
• * Participants must be willing and able to comply with scheduled visits, treatment schedule, laboratory testing, and other requirements of the study.
• 2. Type of Participant and Disease Characteristics
• 1. General
• 1. Target Population
• * Participants must not have a known history of non-infectious pneumonitis that required steroids for treatment.
• * Participants must not have evidence of interstitial lung disease.
• * Participants must not have a current seizure disorder.
• * Participants must not have a history or current evidence of any condition, therapy or laboratory abnormality that might confound the results of the trial, interfere with the subject's participation for the full duration of the trial, or is not in the best interest of the subject to participate, in the opinion of the treating investigator.
• * Has known psychiatric or substance abuse disorders that would interfere with cooperation with the requirements of the trial.
• * Is pregnant or breastfeeding, or expecting to conceive or father children within the projected duration of the trial, starting with the screening visit through 120 days after the last dose of trial treatment.
• * If known active Hepatitis B (e.g., HBsAg reactive) or Hepatitis C is detected then patient is not eligible for treatment of liver lesions
• * Participants must not have had uncontrolled or significant cardiovascular disease including, but not limited to, any of the following:
• * Myocardial infarction or stroke/transient ischemic attack within the past 6 months
• * Uncontrolled angina within the past 3 months
• * Any history of clinically significant arrhythmias (such as ventricular tachycardia, ventricular fibrillation, or torsades de pointes)
• * History of other clinically significant heart disease (e.g. cardiomyopathy, congestive heart failure with New York Heart Association functional classification III to IV, pericarditis, significant pericardial effusion, or myocarditis)
• * Cardiovascular disease-related requirement for daily supplemental oxygen therapy.
• * Participants may not concomitantly use statins while on study. However, a patient using statins for over 3 months prior to study drug administration and in stable status without creatine kinase (CK) rise may be permitted to enroll.
• * Participants may not have current or history of clinically significant muscle disorders (e.g. myositis), recent unresolved muscle injury, or any condition known to elevate serum creatine kinase (CK) levels.
• * Participants must not be prisoners or be involuntarily incarcerated.
• * Participants must not be compulsorily detained for treatment of either a psychiatric or physical (e.g., infectious disease) illness.