Pancreatic Cancer Detection Consortium (PCDC) Prospective Cohorts

Eligibility Criteria

• * PDAC FAMILY HISTORY OR PDAC RELATED GENETIC MUTATIONS:
• * Age: 50 or older, plus at least one of the following:
• * Mutation unknown or absent:
• * 2+ relatives with PDAC on same side of family where 2 affected are first degree related to each other and at least 1 affected is first degree related to subject;
• * OR 2+ affected first degree relatives (FDR), defined as blood related parents, siblings, or children)
• * Known pathogenic/likely pathogenic (P/LP) mutation in at least one of the following:
• * CDKN2A/p16, PJS (STK11), Hereditary pancreatitis with confirmed protease serine 1 (PRSS1)
• * OR 1+FDR or second degree relative (SDR) with PDAC and a known P/LP mutation in one or more of:
• * ATM, BRCA1, BRCA2, PALB2, Lynch syndrome (MLH1, MSH2, MSH6, PMS2, EPCAM), TP53
• * 18 years of age or greater and meeting Fukuoka worrisome (FW) or Fukuoka high-risk (FHR) criteria
• * High risk stigmata:
• * Obstructive Jaundice in a patient with cystic lesion of the head of the pancreas
• * Enhancing mural nodule ≥ 5 mm
• * Main pancreatic duct ≥ 10 mm
• * Worrisome features:
• * Presence of pancreatic duct stricture, defined as focal pancreatic duct narrowing with upstream duct =\> 6 mm
• * Cyst ≥ 3 cm
• * Enhancing mural nodule \< 5 mm
• * Thickened/Enhancing cyst wall
• * Main duct size 5-9 mm
• * Pancreatitis
• * Lymphadenopathy
• * Increased CA 19-9
• * Cyst growth rate ≥ 5 mm /2 years
• * \* Is unable to provide informed consent
• * Has received a non-autologous bone marrow transplant or has an active hematologic malignancy (i.e., leukemia or lymphoma)
• * Current or prior history of PDAC or total pancreatectomy
• * Is currently a prison inmate
• * Is not able to speak or read English