ACTIVE_NOT_RECRUITING

Rapid Diagnosis of Viral Acute Respiratory Infection to Decrease Unnecessary Antibiotic Utilization in the Emergency Department (RADIATE)

Conditions

Acute Respiratory Infection Viral Infection Upper Respiratory Tract Infections Antibiotic Utilization

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The study titled " The Effect of Definitive Identification of Viral Etiology in Emergency Department Patients with Acute Respiratory Infection on Antibiotic Utilization (RADIATE)" aims to investigate the effectiveness of a rapid diagnostic approach in reducing unnecessary antibiotic use in the emergency department (ED) for patients presenting with acute respiratory illness (ARI) due to a virus. Using a prospective design, eligible participants are individuals who visit the ED with complaints related to acute respiratory illness. The study will employ a single-arm consecutive enrollment approach. The intervention involves the implementation of a rapid point-of-care multiplex polymerase chain reaction (PCR) test to promptly identify the viral cause of the infection. By utilizing a rapid diagnostic tool to identify viral etiology, the study aims to provide healthcare professionals in the ED with more accurate information to guide treatment decisions. Ultimately, the goal is to decrease the unnecessary use of antibiotics for ARI's due to a virus, which has several negative outcomes including promotion of antibiotic resistance, exacerbating ED length of stay and encouraging unnecessary additional diagnostic tests.

Official Title

[BFD-RST-23-004] Rapid Diagnosis of Viral Acute Respiratory Infection to Decrease Unnecessary Antibiotic Utilization in the Emergency Department (RADIATE)

Quick Facts

Study Start:2024-03-12

Study Completion:2026-12-31

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:ACTIVE_NOT_RECRUITING

Study ID

NCT06271655

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:No

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* Over the age of 18 * Clinical suspicion of an acute respiratory infection by an emergency department provider * Patient endorses at least ONE symptom of respiratory illness including: cough, sneezing, runny or stuffy nose, sore throat, headaches, muscle aches, trouble breathing, shortness of breath, fever * Patient reports symptoms lasting less than 14 days (i.e., no chronic symptoms) * Patient able to provide informed consent	* Patient is a prisoner or ward of state * Patients that will get antibiotics regardless of of the results of the test (e.g. sepsis, hypoxia, shock, lobar pneumonia, altered mental status, meningitis, pyelonephritis, appendicitis or related, high clinical severity not otherwise specified * Patients who have tested positive for C. diff in the last 60 days * Patients who are hospitalized from the emergency department * Patients that have an oxygen saturation lower than 95% at triage * Altered mental status

Inclusion Criteria

Exclusion Criteria

* Over the age of 18
* Clinical suspicion of an acute respiratory infection by an emergency department provider
* Patient endorses at least ONE symptom of respiratory illness including: cough, sneezing, runny or stuffy nose, sore throat, headaches, muscle aches, trouble breathing, shortness of breath, fever
* Patient reports symptoms lasting less than 14 days (i.e., no chronic symptoms)
* Patient able to provide informed consent

* Patient is a prisoner or ward of state
* Patients that will get antibiotics regardless of of the results of the test (e.g. sepsis, hypoxia, shock, lobar pneumonia, altered mental status, meningitis, pyelonephritis, appendicitis or related, high clinical severity not otherwise specified
* Patients who have tested positive for C. diff in the last 60 days
* Patients who are hospitalized from the emergency department
* Patients that have an oxygen saturation lower than 95% at triage
* Altered mental status

Contacts and Locations

Principal Investigator

Christopher Payette, MD

PRINCIPAL_INVESTIGATOR

George Washington University

Study Locations (Sites)

George Washington University Hospital

Washington DC, District of Columbia, 20037

United States

Collaborators and Investigators

Sponsor: Christopher Payette

Christopher Payette, MD, PRINCIPAL_INVESTIGATOR, George Washington University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-03-12

Study Completion Date2026-12-31

Study Record Updates

Study Start Date2024-03-12

Study Completion Date2026-12-31

Terms related to this study

Keywords Provided by Researchers

Antibiotic Utilization

Additional Relevant MeSH Terms

Acute Respiratory Infection
Viral Infection
Upper Respiratory Tract Infections