Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol (R33)

Description

The proposed project aims to test the cognitive and neural effects of a cognitive training in a sample of individuals seeking treatment for anxiety, depression, or traumatic stress symptoms. Participants will be randomly assigned to one of two groups. Group 1 will receive a computer-based program that is designed as a cognitive training intervention and Group 2 will receive a similar computer-based exercise that researchers think will be less effective in training thinking skills (also known as a control or sham condition). Participants will be compared on cognitive performance and brain response during cognitive tasks from baseline to post-treatment.

Conditions

Anxiety Disorders, Depression, Post Traumatic Stress Disorder

Study Overview

Study Details

Study overview

The proposed project aims to test the cognitive and neural effects of a cognitive training in a sample of individuals seeking treatment for anxiety, depression, or traumatic stress symptoms. Participants will be randomly assigned to one of two groups. Group 1 will receive a computer-based program that is designed as a cognitive training intervention and Group 2 will receive a similar computer-based exercise that researchers think will be less effective in training thinking skills (also known as a control or sham condition). Participants will be compared on cognitive performance and brain response during cognitive tasks from baseline to post-treatment.

Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol

Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol (R33)

Condition
Anxiety Disorders
Intervention / Treatment

-

Contacts and Locations

San Diego

UC San Diego, San Diego, California, United States, 92037

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * age 21-55
  • * fluent in English
  • * diagnosis of mood, anxiety, or traumatic stress disorder
  • * clinically elevated repetitive negative thinking
  • * outpatient status
  • * 6-week stability if taking selective serotonin reuptake inhibitor (SSRI) medications
  • * past year diagnosis of severe alcohol or moderate or greater substance use disorder
  • * lifetime history of psychotic or bipolar I disorder
  • * acute suicidality necessitating immediate clinical intervention
  • * neurodegenerative or neurodevelopmental disorders
  • * history of moderate or severe traumatic brain injury or other known neurological condition
  • * sensory deficits that would preclude completing tasks
  • * conditions unsafe for completing MRI scanning (e.g., metal in body)
  • * current pregnancy
  • * currently receiving psychosocial treatment
  • * currently receiving psychiatric pharmacotherapy, except SSRIs

Ages Eligible for Study

21 Years to 55 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of California, San Diego,

Study Record Dates

2027-08-01