RECRUITING

Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol (R33)

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The proposed project aims to test the cognitive and neural effects of a cognitive training in a sample of individuals seeking treatment for anxiety, depression, or traumatic stress symptoms. Participants will be randomly assigned to one of two groups. Group 1 will receive a computer-based program that is designed as a cognitive training intervention and Group 2 will receive a similar computer-based exercise that researchers think will be less effective in training thinking skills (also known as a control or sham condition). Participants will be compared on cognitive performance and brain response during cognitive tasks from baseline to post-treatment.

Official Title

Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol

Quick Facts

Study Start:2024-10-01
Study Completion:2027-08-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06273527

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:21 Years to 55 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * age 21-55
  2. * fluent in English
  3. * diagnosis of mood, anxiety, or traumatic stress disorder
  4. * clinically elevated repetitive negative thinking
  5. * outpatient status
  6. * 6-week stability if taking selective serotonin reuptake inhibitor (SSRI) medications
  1. * past year diagnosis of severe alcohol or moderate or greater substance use disorder
  2. * lifetime history of psychotic or bipolar I disorder
  3. * acute suicidality necessitating immediate clinical intervention
  4. * neurodegenerative or neurodevelopmental disorders
  5. * history of moderate or severe traumatic brain injury or other known neurological condition
  6. * sensory deficits that would preclude completing tasks
  7. * conditions unsafe for completing MRI scanning (e.g., metal in body)
  8. * current pregnancy
  9. * currently receiving psychosocial treatment
  10. * currently receiving psychiatric pharmacotherapy, except SSRIs

Contacts and Locations

Study Contact

Jessica Bomyea, Ph.D.
CONTACT
858.552.8585
jbomyea@health.ucsd.edu

Study Locations (Sites)

UC San Diego
San Diego, California, 92037
United States

Collaborators and Investigators

Sponsor: University of California, San Diego

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-10-01
Study Completion Date2027-08-01

Study Record Updates

Study Start Date2024-10-01
Study Completion Date2027-08-01

Terms related to this study

Additional Relevant MeSH Terms

  • Anxiety Disorders
  • Depression
  • Post Traumatic Stress Disorder