COMPLETED

Deprescribing Potentially Inappropriate Medications in the Emergency Department for Persons Living With Dementia

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Aim 1: To demonstrate the feasibility by determining proportion of completed medication reconciliation, Central Nervous System active Potentially Inappropriate Medication (CNS PIM) use among patients with Alzheimer's Disease and Related Dementias (ADRD) and Mild Cognitive Impairment (MCI) in the emergency department (ED), and communication between ED clinical pharmacists and outpatient prescribers. Aim 2: To demonstrate the feasibility of collecting the primary and secondary outcomes for a subsequent study. The future primary outcome will be reduction in CNS PIMs 90 days after an ED visit. Secondary outcomes will include outpatient follow-up, repeat ED visits, and hospitalizations during the 90 days following an ED visit. Aim 3: To demonstrate the acceptability of the PRIDE intervention to outpatient clinicians using the Acceptability of Intervention Measure and qualitative analysis of responses.

Official Title

Deprescribing Potentially Inappropriate Medications in the Emergency Department for Persons Living With Dementia

Quick Facts

Study Start:2024-07-09
Study Completion:2025-10-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:COMPLETED

Study ID

NCT06273917

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 120 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Community dwelling
  2. * 18 years of age or older
  3. * History of dementia or mild cognitive impairment in the problem list in the NM EHR. A history of mild cognitive impairment will be identified using the ICD-10 code G31.84 (mild cognitive impairment) or ICD-10 codes suggestive of ADRD as described in the Bynum-standard algorithm: F01.50-F01.51 (vascular dementia), F02.80-F02.81 (dementia), F03.90-F03.91 (unspecified dementia), F04 (amnestic disorder), G30.0/30.1/30.8/G30.9 (Alzheimer's disease), G31.01 (Pick's disease), G31.09 (frontotemporal dementia), G31.83 (dementia with Lewy bodies), G31.1 (senile degeneration), G31.2 (degeneration of nervous system), R41.81 (age-related cognitive decline).
  4. * Able to participate in medication reconciliation as determined by the pharmacist per usual care OR a care partner with knowledge of the patient's current medications is present in the ED or is available by phone.
  5. * Has had prior outpatient care performed at Northwestern Medicine location(s)
  6. * Arrives to the emergency department between 7am and 7pm, Monday-Friday
  1. * Emergency Severity Index (ESI) of 1 (critical)
  2. * ICU consult placed in the ED
  3. * Reside in nursing facility or assisted living facility

Contacts and Locations

Principal Investigator

Scott Dresden, Dr.
PRINCIPAL_INVESTIGATOR
Northwestern University- Department of Emergency Medicine

Study Locations (Sites)

Northwestern Memorial Hospital
Chicago, Illinois, 60611
United States
Northwestern Medicine Lake Forest Hospital
Lake Forest, Illinois, 60045
United States
Northwestern Medicine Palos Hospital
Palos Heights, Illinois, 60463
United States

Collaborators and Investigators

Sponsor: National Institute on Aging (NIA)

  • Scott Dresden, Dr., PRINCIPAL_INVESTIGATOR, Northwestern University- Department of Emergency Medicine

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-07-09
Study Completion Date2025-10-31

Study Record Updates

Study Start Date2024-07-09
Study Completion Date2025-10-31

Terms related to this study

Keywords Provided by Researchers

  • Depresribing Medication

Additional Relevant MeSH Terms

  • Dementia