The Effect of Teprotumumab on Thyroid Eye Disease and Thyroid Dysfunction

Description

This protocol studies the clinical outcome of patients with active thyroid disease with visually significant signs and symptoms of proptosis, pain, diplopiam lid/orbital edema, or lid/orbital erythema recommended for treatment with teprotumumab infusion (Tepezza®). Patients recommended for treatment will be evaluated by an oculoplastic surgeon (Dr. Eva Chou) and endocrinologist (Dr. Thanh Hoang).

Conditions

Thyroid Eye Disease, Graves Ophthalmopathy, Graves Disease

Study Overview

Study Details

Study overview

This protocol studies the clinical outcome of patients with active thyroid disease with visually significant signs and symptoms of proptosis, pain, diplopiam lid/orbital edema, or lid/orbital erythema recommended for treatment with teprotumumab infusion (Tepezza®). Patients recommended for treatment will be evaluated by an oculoplastic surgeon (Dr. Eva Chou) and endocrinologist (Dr. Thanh Hoang).

The Effect of Teprotumumab on Thyroid Eye Disease and Thyroid Dysfunction

The Effect of Teprotumumab on Thyroid Eye Disease and Thyroid Dysfunction

Condition
Thyroid Eye Disease
Intervention / Treatment

-

Contacts and Locations

Bethesda

Walter Reed National Military Medical Center, Bethesda, Maryland, United States, 20889

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * only DOD beneficiaries
  • * adult patients 18 years of age or older
  • * adult patients with proptosis, ocular/orbital pain, diplopia, lid/orbital edema, or lid/orbital erythema associated with autoimmune thyroid disease
  • * Patients with evidence of compressive optic neuropathy necessitating urgent orbital decompression or external beam radiation
  • * patients with a history of uncontrolled diabetes mellitus
  • * patients with a history/diagnosis of uncontrolled inflammatory bowel disease
  • * patients under age 18 years
  • * patients who are pregnant or trying to become pregnant.

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Walter Reed National Military Medical Center,

Thanh D Hoang, DO, PRINCIPAL_INVESTIGATOR, Walter Reed National Military Medical Center

Study Record Dates

2027-12-12