TERMINATED

The Effect of the Inclusion of Soybean Flour on Glycemic Responses

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Foods that release glucose rapidly, leading to spikes in blood sugar and insulin (known as high glycemic index foods), generate lower satiety responses than foods with low glycemic index. High glycemic index foods are also linked to an increased risk of developing diabetes. The partial replacement of carbohydrates in rich staple foods with soy flour has the potential to reduce glycemic response and improve satiety. In many regions of Latin America, as well as in the Middle East and North Africa (MENA) regions, bread is the staple source of calories, but it is a relatively poor source of balanced nutrition. Bread enriched with soy flour could provide higher dietary protein while moderating blood glucose (and insulin) spikes, which can help reduce insulin resistance and metabolic diseases. The results of this study could provide government and private human nutritionists with the evidence they need to formulate soy flour into bread, corn tortillas, and arepas for schools and homes.

Official Title

The Effect of the Inclusion of Soybean Flour on Glycemic Responses of Bread, Tortilla, and Arepa to Enhance Human Nutrition

Quick Facts

Study Start:2024-03-11
Study Completion:2025-06-20
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:TERMINATED

Study ID

NCT06280625

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:21 Years to 45 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * Male and female between 21-45 years of age
  2. * All races/ethnicities
  3. * Body mass Index (BMI) \> 25 kg/m2 and \<40 kg/m2 (i.e., overweight and obesity, excluding severe obesity)
  4. * Fat %: \> 30% for female or \> 20% for male
  1. * Currently smokes or quit smoking nicotine cigarettes, vapes or E-cigarettes for less than 6 months ago
  2. * Pregnant, breastfeeding, menopausal
  3. * Hemoglobin: \<11g/dl for female and \<13g/dl for male
  4. * Blood donation in the past 8 weeks
  5. * Gluten intolerance (Gluten allergy, wheat allergy, celiac disease), Soy intolerance or allergy
  6. * Presence of malabsorption syndrome
  7. * History of bariatric surgery
  8. * Presence of inflammatory intestinal disease, liver, or kidney disease
  9. * Diabetes (fasting glucose level \>126mg/dl or plasma glucose level 2h after glucose challenge \>200 mg/dl) or taking medicines to treat diabetes
  10. * Polycystic ovary syndrome (pcos)
  11. * Untreated hypertension
  12. * Taking any medication that might affect glucose metabolism or the results of our study
  13. * History of cancer \<5 years ago
  14. * Abnormalities in the metabolic panel test (e.g., liver enzymes \>2 times the upper limit).
  15. * Seizures

Contacts and Locations

Principal Investigator

Marta Y Pepino de Gruev, PhD
PRINCIPAL_INVESTIGATOR
University of Illinois at Urbana-Champaign

Study Locations (Sites)

University of Illinois at Urbana Champaign
Champaign, Illinois, 61820
United States

Collaborators and Investigators

Sponsor: University of Illinois at Urbana-Champaign

  • Marta Y Pepino de Gruev, PhD, PRINCIPAL_INVESTIGATOR, University of Illinois at Urbana-Champaign

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-03-11
Study Completion Date2025-06-20

Study Record Updates

Study Start Date2024-03-11
Study Completion Date2025-06-20

Terms related to this study

Keywords Provided by Researchers

  • glycemic responses
  • insulin
  • satiety

Additional Relevant MeSH Terms

  • Overweight and Obesity