Liposomal Bupivacaine Use in Alveolar Bone Graft Patients

Description

The goal of this clinical trial is to learn if a pain medication called liposomal bupivacaine (brand name EXPAREL®) with epinephrine will provide better pain control, increased activity, and reduced use of opioids compared with the standard treatment for patients age 6 years and older with cleft lip and palate who have had an alveolar bone graft surgery. Investigators will look at: * pain scores at hip and jaw sites * opioid use in amount and frequency * scores on activity questionnaires Researchers will compare the results of these items with those of patients who had the standard treatment of bupivacaine with epinephrine.

Conditions

Cleft Lip and Palate

Study Overview

Study Details

Study overview

The goal of this clinical trial is to learn if a pain medication called liposomal bupivacaine (brand name EXPAREL®) with epinephrine will provide better pain control, increased activity, and reduced use of opioids compared with the standard treatment for patients age 6 years and older with cleft lip and palate who have had an alveolar bone graft surgery. Investigators will look at: * pain scores at hip and jaw sites * opioid use in amount and frequency * scores on activity questionnaires Researchers will compare the results of these items with those of patients who had the standard treatment of bupivacaine with epinephrine.

Liposomal Bupivacaine Use in Alveolar Bone Graft Patients

Liposomal Bupivacaine Use in Alveolar Bone Graft Patients

Condition
Cleft Lip and Palate
Intervention / Treatment

-

Contacts and Locations

Chicago

Shriners Children's Chicago, Chicago, Illinois, United States, 60707

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Patients that are 6 and older who have a diagnosis of cleft lip and/or palate with a scheduled surgery that involves an alveolar bone graft.
  • * Patients under age 6 are excluded from this study as EXPAREL® is not FDA approved for this group.
  • * Patients with a history of allergic or adverse reaction to any drug involved in the study (EXPAREL, Epinephrine, or Bupivacaine).
  • * Patients with a history of cardiovascular disease.

Ages Eligible for Study

6 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Kerry O'Rourke,

Chad A. Purnell, MD, PRINCIPAL_INVESTIGATOR, Shriners Hospitals for Children

Study Record Dates

2026-04-24