Nerve Transfer to Improve Function in High Level Tetraplegia

Description

The goal of this observational study is to determine if nerve transfer surgeries improve upper extremity function and quality of life in patients with a high level cervical spinal cord injury. Participants will: * undergo standard of care pre- and post-op testing and study exams * complete pre- and post-questionnaires * undergo standard of care nerve transfer surgeries * follow-up with surgeon at 6/12/18/24/36 and potentially at 48 months * attend therapy at local therapist for up to 2 years postop.

Conditions

Cervical Spinal Cord Injury, Tetraplegia

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Study Overview

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Study Details

Study overview

The goal of this observational study is to determine if nerve transfer surgeries improve upper extremity function and quality of life in patients with a high level cervical spinal cord injury. Participants will: * undergo standard of care pre- and post-op testing and study exams * complete pre- and post-questionnaires * undergo standard of care nerve transfer surgeries * follow-up with surgeon at 6/12/18/24/36 and potentially at 48 months * attend therapy at local therapist for up to 2 years postop.

Nerve Transfer to Restore Upper Limb Function and Quality of Life in High Tetraplegia

Nerve Transfer to Improve Function in High Level Tetraplegia

Condition
Cervical Spinal Cord Injury
Intervention / Treatment

-

Contacts and Locations

Stanford

Stanford University, Stanford, California, United States, 94305

Miami

University of Miami, Miami, Florida, United States, 33136

Baltimore

Johns Hopkins University, Baltimore, Maryland, United States, 21287

Ann Arbor

University of Michigan, Ann Arbor, Michigan, United States, 48109

Saint Louis

Washington University in St. Louis, Saint Louis, Missouri, United States, 63110

Philadelphia

University of Pennsylvania, Philadelphia, Pennsylvania, United States, 19104

Houston

Houston Methodist, Houston, Texas, United States, 77030

Salt Lake City

University of Utah, Salt Lake City, Utah, United States, 84132

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * 18-80 years of age
  • * High cervical SCI (motor level C1-C4)
  • * Motor complete SCI AIS grade A-B
  • * Plateaued spontaneous recovery for at least 6 months of non-operative therapy
  • * SCI greater than 6 months and fewer than 60 months since injury
  • * At least MRC 4/5 donor strength
  • * Mentally and physically willing and able to comply with evaluations
  • * Active infection at the operative site or systemic infection
  • * Any return or ongoing recovery of distal motor function
  • * Significant joint contractures and/or limitations in passive range of motion in the arm
  • * Mentally or physically compromised making it impossible to complete study activities
  • * Immunologically suppressed
  • * Currently undergoing long-term steroid therapy
  • * Active malignancy
  • * Pregnancy

Ages Eligible for Study

18 Years to 80 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Washington University School of Medicine,

Wilson Z. Ray, MD, PRINCIPAL_INVESTIGATOR, Washington University School of Medicine

Study Record Dates

2028-12-31