Study of Ravulizumab in Immunoglobulin A Nephropathy (IgAN)

Eligibility Criteria

• * Documentation of IgAN diagnosis established on kidney biopsy obtained any time prior to or during the Screening Period for participants with eGFR ≥ 30 mL/min/1.73 m\^2.
• * For participants in the AdKD cohorts, eGFR 20 to 29 mL/min/1.73 m2 a kidney biopsy is required within 6 months prior to Screening or during the Screening Period.
• * UPCR ≥ 0.75 g/g or UP ≥1 g/day calculated from the mean of two 24-hour urine during the Screening Period.
• * Estimated GFR ≥ 30 mL/min/1.73 m2 at Screening.
• * Stable and maximum allowed or tolerated RASI (ACEI and/or ARB) dose for ≥ 3 months prior to Screening with no planned change during Screening through Week 106.
• * Participants who are receiving SGLT2I, DEARA, MRA or ERA must be on a stable and maximum allowed or tolerated dose for ≥ 3 months prior to Screening with no planned change in dose through Week 106.
• * Diagnosis of rapid progressive glomerulonephritis as measured by eGFR loss ≥ 50% over a period of 3 months prior to Screening.
• * Secondary IgAN (eg, due to systemic lupus erythematosus (SLE), cirrhosis, or celiac disease; IgAV-N may be eligible).
• * Concomitant clinically significant renal disease other than IgAN.
• * Prior use of immunosuppressive treatment within 3 months of screening.
• * Uncontrolled diabetes mellitus with glycosylated hemoglobin (HbA1c) \> 8.5%.
• * Henoch-Schonlein purpura (IgAV) requiring systemic immunosuppressive therapy within 12 months of Screening.
• * History of kidney transplant or planned kidney transplant during the Treatment Period.
• * Splenectomy or functional asplenia.
• * History of Neisseria meningitidis infection.
• * Active systemic bacterial, viral, or fungal infection within 14 days prior to randomization.