Mepivacaine vs Bupivacaine Spinal Anesthesia for TKA

Description

This study is a prospective, double-blind prospective randomized controlled trial comparing mepivacaine and bupivacaine spinal anesthesia for same-day discharge readiness following a unilateral primary elective TKA procedure. Study data will be collected during the patient's hospital stay for their TKA procedure, and the primary outcome of same-day discharge readiness will be assessed the day of surgery. Patients will also be contacted at Day 3 post-op to assess for any complications, current level of pain, and pain medication utilization.

Conditions

Anesthesia, Spinal, Arthroplasty, Replacement, Knee

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Study Overview

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Study Details

Study overview

This study is a prospective, double-blind prospective randomized controlled trial comparing mepivacaine and bupivacaine spinal anesthesia for same-day discharge readiness following a unilateral primary elective TKA procedure. Study data will be collected during the patient's hospital stay for their TKA procedure, and the primary outcome of same-day discharge readiness will be assessed the day of surgery. Patients will also be contacted at Day 3 post-op to assess for any complications, current level of pain, and pain medication utilization.

Mepivacaine Versus Bupivacaine Spinal Anesthesia for Same Day Discharge Following Total Knee Arthroplasty

Mepivacaine vs Bupivacaine Spinal Anesthesia for TKA

Condition
Anesthesia, Spinal
Intervention / Treatment

-

Contacts and Locations

Greenville

Prisma Health Patewood Hospital, Greenville, South Carolina, United States, 29615

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Patient is at least 18 years of age who are scheduled for a primary elective TKA.
  • * Patient can ambulate at least 10 feet independently without human assistance.
  • * Patient must be a candidate for same day discharge as determined by American Society of Anesthesiologists (ASA) Physical Status Classification I and II
  • * Patients scheduled for bilateral TKAs
  • * Contraindication to spinal anesthesia
  • * Revision TKAs
  • * Allergy or contraindication to NSAIDs (e.g. chronic anti-coagulant use)
  • * Workers' Compensation patient
  • * Type I Diabetes
  • * Type II Diabetes requiring insulin medication.
  • * Pre-operative narcotics use with the exception of tramadol.
  • * Renal insufficiency (GFR \< 60) that may impact post-operative protocol
  • * Cognitive deficiencies that prevent the patient from providing their own informed consent
  • * Language barrier preventing completion of study forms in English

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Prisma Health-Upstate,

Study Record Dates

2025-09-01