Obinutuzumab in Treatment of Fibrillary Glomerulonephritis

Eligibility Criteria

• * ≥18 years of age
• * Biopsy proven fibrillary glomerulonephritis
• * Proteinuria \> 1.0 g/24hrs prior to initiation of immunosuppressive therapy
• * eGFR ≥ 20 ml/min/BSA
• * Secondary FGN (due to monoclonal gammopathy, autoimmune disease or malignancy)
• * Presence of a secondary pathology on biopsy (e.g. diabetic nephropathy)
• * Hepatitis B, C or HIV positive
• * Pregnant or breast-feeding
• * Active infection
• * Kidney transplant
• * Anemia with Hgb \< 8.0 g/dL
• * Thrombocytopenia with platelet count \< 100'000
• * Any other disease, metabolic dysfunction, physical examination finding, or clinical laboratory finding giving reasonable suspicion of a disease or condition that contraindicates the use of an investigational drug or that may affect the interpretation of the results or render the patient at high risk from treatment complication
• * Patients who have received cyclophosphamide in the last 6 months
• * Patients who have received ACTH and/or mycophenolate mofetil in the last 30 days
• * Patient who are on prednisone therapy at a dose \> 10 mg/day in the last 15 days
• * Patients who received rituximab previously with CD20 count of \< 5 cells/microliter at the time of enrollment
• * For women who are not postmenopausal (greater than or equal to \[\>/=\] 12 months of non-therapy-induced amenorrhea) or surgically sterile (absence of ovaries and/or uterus): agreement to remain abstinent or use two adequate methods of contraception, including at least one method with a failure rate of less than (\<) 1 percent (%) per year, during the treatment period and for at least 18 months after the last dose of study drug
• * For men: agreement to remain abstinent or use two adequate methods for contraception, including at least one method with failure rate of less than 1% per year during the treatment period and for at least 6 months (180 days) after the last dose of drug