Massed Prolonged Exposure for PTSD in Substance Use Treatment

Description

The goal of this clinical trial is to learn if receiving Prolonged Exposure Therapy for PTSD in massed format (multiple sessions weekly) is as effective as receiving it with sessions once per week among veterans with PTSD and substance use disorder in intensive outpatient substance use treatment. The main questions it aims to answer are: * Will the massed format help participants complete and benefit from Prolonged Exposure in terms of PTSD symptoms? * Will it help participants reduce substance use? Participants who are in intensive substance use treatment will be asked to complete Prolonged Exposure with either weekly sessions or multiple sessions per week.

Conditions

Stress Disorders, Post-Traumatic, Substance Use Disorders

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Study Overview

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Study Details

Study overview

The goal of this clinical trial is to learn if receiving Prolonged Exposure Therapy for PTSD in massed format (multiple sessions weekly) is as effective as receiving it with sessions once per week among veterans with PTSD and substance use disorder in intensive outpatient substance use treatment. The main questions it aims to answer are: * Will the massed format help participants complete and benefit from Prolonged Exposure in terms of PTSD symptoms? * Will it help participants reduce substance use? Participants who are in intensive substance use treatment will be asked to complete Prolonged Exposure with either weekly sessions or multiple sessions per week.

Clinical Effectiveness and Implementation of Massed Prolonged Exposure for PTSD Among Veterans in Intensive Outpatient Substance Use Treatment (MPE)

Massed Prolonged Exposure for PTSD in Substance Use Treatment

Condition
Stress Disorders, Post-Traumatic
Intervention / Treatment

-

Contacts and Locations

San Diego

VA San Diego Healthcare System, San Diego, California, United States, 92161

Tampa

VA Tampa Healthcare System, Tampa, Florida, United States, 33612

Atlanta

VA Atlanta Healthcare System, Atlanta, Georgia, United States, 30033

Chicago

Hines VA Healthcare System, Chicago, Illinois, United States, 60141

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Veterans
  • * age 18+
  • * who have served since September 2001
  • * who are enrolled in a SUD IOP at a participating VA
  • * meet DSM-5 criteria for a current SUD (Tobacco Use Disorder alone not sufficient for inclusion)
  • * meet DSM-5 criteria for PTSD
  • * report substance use at least 20 of the last 90 days
  • * are able to give informed consent.
  • * severe cognitive impairment
  • * current suicidal or homicidal intent requiring immediate treatment
  • * current unstable psychotic or manic symptoms not attributable to SUD

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Veterans Medical Research Foundation,

Shannon Kehle-Forbes, PhD, PRINCIPAL_INVESTIGATOR, University of Minnesota

Study Record Dates

2027-08