Trauma-Informed Guilt Reduction Therapy Compared to Prolonged Exposure

Description

The goal of this clinical trial is to learn if receiving Trauma-Informed Guilt Reduction (TrIGR) Therapy is as effective as receiving Prolonged Exposure Therapy among veterans with PTSD and trauma related guilt. The main questions it aims to answer are: Will TrIGR be comparable to PE in terms of PTSD symptom reduction? Will it TrIGR be comparable to PE in improving functioning and reducing depression symptoms? Will it be superior in improving trauma-related guilt and shame?

Conditions

Stress Disorders, Post-Traumatic

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Study Overview

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Study Details

Study overview

The goal of this clinical trial is to learn if receiving Trauma-Informed Guilt Reduction (TrIGR) Therapy is as effective as receiving Prolonged Exposure Therapy among veterans with PTSD and trauma related guilt. The main questions it aims to answer are: Will TrIGR be comparable to PE in terms of PTSD symptom reduction? Will it TrIGR be comparable to PE in improving functioning and reducing depression symptoms? Will it be superior in improving trauma-related guilt and shame?

Clinical Effectiveness and Implementation of Trauma-Informed Guilt Reduction Therapy Compared to Prolonged Exposure (TrIGR)

Trauma-Informed Guilt Reduction Therapy Compared to Prolonged Exposure

Condition
Stress Disorders, Post-Traumatic
Intervention / Treatment

-

Contacts and Locations

Little Rock

Little Rock Veterans Health Care System (LRVHCS), Little Rock, Arkansas, United States, 72205

New Orleans

Southeast Louisiana Veterans Health Care System (SLVHCS), New Orleans, Louisiana, United States, 70119

Madison

William S. Middleton Memorial Hospital, Madison, Wisconsin, United States, 53705

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * U.S. Veterans age 18 or older who served in the military since the start of Operation Enduring Freedom/Operation Iraqi Freedom; OEF/OIF)
  • * meets diagnostic criteria for PTSD;
  • * a score of 2 or higher ("true" to "extremely true") on feeling trauma-related guilt much or all of the time or scoring 3 or higher ("very true" or "extremely true") on at least one guilt cognition factor (hindsight bias/responsibility, wrongdoing, or lack of justification) on the Trauma Related Guilt Inventory
  • * not currently receiving trauma-focused treatment such as PE or CPT
  • * willingness to attend psychotherapy and assessment sessions
  • * current risk of suicidal/homicidal behavior that requires immediate intervention
  • * current severe substance use disorder (in the past two months) based on DSM-5 criteria
  • * current unmanaged psychosis or mania
  • * life threatening or unstable medical illness
  • * inability to read

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Veterans Medical Research Foundation,

Shannon Kehle-Forbes, PhD, PRINCIPAL_INVESTIGATOR, University of Minnesota

Study Record Dates

2027-08