Study of STP938 in Advanced Solid Tumours

Eligibility Criteria

• * Signed and dated informed consent, and able to comply with the study procedures and any locally required authorization.
• * Male or female aged ≥ 18 years.
• * Advanced disease not curable by available therapies and requires systemic therapy.
• * Histologically confirmed diagnosis of eligible cancer type.
• * Must have tumor tissue available for biomarker testing.
• * Measurable disease (Part 1) and measurable disease per RECIST (Part2)
• * Eastern Cooperative Oncology Group (ECOG) performance status ≤2.
• * Life expectancy \> 3 months as assessed by the Investigator.
• * Adequate organ function (bone marrow, hepatic, renal function and coagulation).
• * All toxicities (except alopecia) from prior cancer treatments or procedures must have resolved to ≤Grade 1 or returned to baseline levels prior to enrollment.
• * Pregnant or breastfeeding females and women of childbearing potential or males unwilling to comply with contraception requirements.
• * Known active or symptomatic CNS metastases, carcinomatous meningitis, leptomeningeal disease or a history of spinal cord compression
• * Active malignancy within 2 years of study enrollment
• * Prior radiation within 2 weeks of start of therapy.
• * Systemic cancer treatments, monoclonal antibody-directed therapies, other investigational agents within 4 weeks before enrollment, or \<5 half-lives since completion of previous investigational therapy, whichever is shorter.
• * Uncontrolled intercurrent illness.
• * Immunocompromised subjects with increased risk of opportunistic infections or history of opportunistic infection in the last 12 months.
• * Known active or chronic hepatitis B or active hepatitis C virus (HCV) infection.
• * Subjects with corrected QT interval \>470 msec based on averaged triplicate electrocardiogram (ECG) readings at the Screening Visit using the QT interval corrected for heart rate using Fridericia's method (QTcF).