Effect of Retatrutide Compared With Placebo in Participants With Type 2 Diabetes and Moderate or Severe Renal Impairment, With Inadequate Glycemic Control on Basal Insulin, With or Without Metformin and/or SGLT2 Inhibitor (TRANSCEND-T2D-3)

Eligibility Criteria

• * Have Type 2 Diabetes (T2D)
• * Have HbA1c ≥7.0% (53 millimoles per mole (mmol/mol)) to ≤10.5% (91 mmol/mol)
• * Have moderate or severe renal impairment
• * Have been on the following stable diabetes treatment during 90 days prior to screening
• * basal insulin (≥20 International Units (IU)/day) with or without
• * metformin and/or SGLT2 inhibitor
• * Are of stable weight for at least 90 days prior to screening
• * Have a Body Mass Index (BMI) ≥23.0 kilograms per meter squared (kg/m2)
• * Have Type 1 Diabetes (T1D)
• * Have a history of ketoacidosis or hyperosmolar state or coma within the last 6 months prior to screening
• * Have a history of severe hypoglycemia or hypoglycemia unawareness within the last 6 months prior to screening
• * Are currently receiving or planning to receive treatment for diabetic retinopathy and/or macular edema
• * Have a history of unstable or rapidly progressing renal disease
• * Have a prior or planned surgical treatment for obesity
• * Have New York Heart Association Functional Classification III or IV congestive heart failure
• * Have had acute myocardial infarction, stroke, or were hospitalized for congestive heart failure within 90 days prior to screening
• * Have a known clinically significant gastric emptying abnormality
• * Have a history of an active or untreated malignancy or are in remission from a clinically significant malignancy for less than 5 years
• * Have a family or personal history of medullary thyroid carcinoma or multiple endocrine neoplasia (MEN) syndrome Type 2.
• * Have any lifetime history of a suicide attempt
• * Had chronic or acute pancreatitis
• * Have taken prescribed or over-the-counter medication, or alternative remedies, intended to promote body weight reduction within 90 days prior to screening