TERMINATED

Descartes-15 for Patients With Relapsed/Refractory Multiple Myeloma

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This is a Phase I dose-escalation study to evaluate the safety, tolerability and preliminary efficacy of an autologous BCMA-targeting RNA-engineered CAR T-cell therapy in patients with Relapsed/Refractory Multiple Myeloma. The cell product is referred to as Descartes-15

Official Title

Descartes-15 for Patients With Relapsed/Refractory Multiple Myeloma

Quick Facts

Study Start:2024-06-19
Study Completion:2025-11-13
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:TERMINATED

Study ID

NCT06304636

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Locations (Sites)

Center for Cancer and Blood Disorders (AON)
Bethesda, Maryland, 20817
United States

Collaborators and Investigators

Sponsor: Cartesian Therapeutics

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-06-19
Study Completion Date2025-11-13

Study Record Updates

Study Start Date2024-06-19
Study Completion Date2025-11-13

Terms related to this study

Keywords Provided by Researchers

  • Relapsed/Refractory
  • Relapsed Myeloma
  • Refractory Myeloma
  • Multiple Myeloma
  • Car-T
  • CART
  • Descartes-15
  • Descartes
  • Myeloma
  • T cells
  • cell gene

Additional Relevant MeSH Terms

  • Refractory Multiple Myeloma
  • Relapsed Multiple Myeloma