A Study to Assess IPN01194 When Administered Alone in Adults With Advanced Solid Tumours

Description

The purpose of this study is to determine the appropriate dosage, safety and effectiveness of the study drug, IPN01194 in adults with advanced solid tumours. The participants in this study will have advanced solid tumours. 'Advanced solid tumours' refers to cancers that can occur in several places, including cancers in organs or tissues that have spread from their original site to nearby tissues or other parts of the body. In this study, all participants will receive the study drug, which will be taken by mouth (orally).

Conditions

Melanoma, Head and Neck Squamous Cell Carcinoma, Pancreatic Ductal Adenocarcinoma, Colorectal Cancer, Solid Tumor

Study Overview

Study Details

Study overview

The purpose of this study is to determine the appropriate dosage, safety and effectiveness of the study drug, IPN01194 in adults with advanced solid tumours. The participants in this study will have advanced solid tumours. 'Advanced solid tumours' refers to cancers that can occur in several places, including cancers in organs or tissues that have spread from their original site to nearby tissues or other parts of the body. In this study, all participants will receive the study drug, which will be taken by mouth (orally).

An Open-label, Phase I/IIa First-in-human, Dose Escalation and Cohort Expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetic, Pharmacodynamic and Antitumour Activity of ERK1/2 Inhibitor IPN01194 as Single Agent in Adult Participants With Advanced Solid Tumours

A Study to Assess IPN01194 When Administered Alone in Adults With Advanced Solid Tumours

Condition
Melanoma
Intervention / Treatment

-

Contacts and Locations

Los Angeles

The Angeles Clinic and Research Institute - California, Los Angeles, California, United States, 90025

San Diego

UC San Diego Health System - La Jolla, San Diego, California, United States, 92037

New Haven

Yale Cancer Center - New Heaven, New Haven, Connecticut, United States, 06510

Nashville

Sarah Cannon Research Institute (SCRI) - Nashville, Nashville, Tennessee, United States, 37203

Fairfax

Virginia Cancer Specialist, Fairfax, Virginia, United States, 22031

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

    Ages Eligible for Study

    18 Years to

    Sexes Eligible for Study

    ALL

    Accepts Healthy Volunteers

    No

    Collaborators and Investigators

    Ipsen,

    Ipsen Medical Director, STUDY_DIRECTOR, Ipsen

    Study Record Dates

    2028-03-20