Adaption of the STAIR-NT Trauma Intervention for Polysubstance Populations

Description

During this 36-month R34 trial, eight study phases are proposed to adapt an evidence-based post traumatic stress disorder (PTSD) intervention (STAIR-NT) and layer it into a methadone maintenance treatment (MMT) program (START Treatment and Recovery centers) in New York City for use among individuals engaged in stimulant-opioid polysubstance use. The study aims to adapt STAIR-NT to a massed treatment schedule. Once an adapted protocol is complete, it will be tested for feasibility, acceptability, and short-term polysubstance and PTSD symptomology outcomes in a pilot randomized control trial (RCT) of 80 participants. Participants who screen eligible and consent will be randomized 1:1 to the adapted STAIR-NT intervention or treatment as usual (TAU) using randomization blocks of two and two and four via a computer-generated randomization sequence. Participants assigned to the intervention will receive the adapted massed delivery of STAIR-NT by trained counselors.

Conditions

Polysubstance Abuse, Posttraumatic Stress Disorder

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Study Overview

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Study Details

Study overview

During this 36-month R34 trial, eight study phases are proposed to adapt an evidence-based post traumatic stress disorder (PTSD) intervention (STAIR-NT) and layer it into a methadone maintenance treatment (MMT) program (START Treatment and Recovery centers) in New York City for use among individuals engaged in stimulant-opioid polysubstance use. The study aims to adapt STAIR-NT to a massed treatment schedule. Once an adapted protocol is complete, it will be tested for feasibility, acceptability, and short-term polysubstance and PTSD symptomology outcomes in a pilot randomized control trial (RCT) of 80 participants. Participants who screen eligible and consent will be randomized 1:1 to the adapted STAIR-NT intervention or treatment as usual (TAU) using randomization blocks of two and two and four via a computer-generated randomization sequence. Participants assigned to the intervention will receive the adapted massed delivery of STAIR-NT by trained counselors.

Adaption of the STAIR-NT Trauma Intervention for Polysubstance Populations

Adaption of the STAIR-NT Trauma Intervention for Polysubstance Populations

Condition
Polysubstance Abuse
Intervention / Treatment

-

Contacts and Locations

Tallahassee

Florida State University, Tallahassee, Florida, United States, 32306

Brooklyn

START Treatment and Recovery Centers, Brooklyn, New York, United States, 11238

New York

NYU Langone Health, New York, New York, United States, 10016

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * must be 18 years or older,
  • * be a patient at the START clinic receiving methadone for treatment of opioid use disorder,
  • * self-report 10+ days of co-use of cocaine and illicit opioids in the past 30-days,
  • * meet the criteria for stimulant use disorder (cocaine type; mild, moderate or severe) and a score of 3≥ on the PC-PTSD-5.
  • * cognitive impairment that would interfere with their ability to understand study participation as assessed by the researcher,
  • * does not speak/understand English at a conversational level,
  • * plans to leave the START clinic in the next 60 days,
  • * patients who missed methadone doses (inactive) for 30 days or more, or
  • * having received clinical care from the interventionist(s) in the past 30 days

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

NYU Langone Health,

Amanda Bunting, PRINCIPAL_INVESTIGATOR, NYU Langone Health

Study Record Dates

2026-04-30