Sparking Gut Bacteria Production of Bioactive Xenolipids in Situ

Description

Long-chain cyclopropane fatty acids (CpFAs) are microbially-derived lipids (fats), some of which can be found in select foods and appear to be produced naturally in the gut from dietary fatty acid precursors. Some of these lipids appear to have signaling properties in the body's tissues, i.e., to help regulate cardiometabolic health. Thus, increasing the bioavailability of CpFAs in humans may have utility to improve management of blood sugar and blood lipids, or to mitigate or prevent non-alcoholic fatty liver disease (NAFLD). This study is a proof-of-principle experiment in 10 subjects, to feed dietary fats thought to enhance upper gut CpFA production. The latter will be monitored through post-meal blood and urine CpFA concentration measurements, as well as concentration in the stool.

Conditions

Dietary Fat Metabolism

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Study Overview

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Study Details

Study overview

Long-chain cyclopropane fatty acids (CpFAs) are microbially-derived lipids (fats), some of which can be found in select foods and appear to be produced naturally in the gut from dietary fatty acid precursors. Some of these lipids appear to have signaling properties in the body's tissues, i.e., to help regulate cardiometabolic health. Thus, increasing the bioavailability of CpFAs in humans may have utility to improve management of blood sugar and blood lipids, or to mitigate or prevent non-alcoholic fatty liver disease (NAFLD). This study is a proof-of-principle experiment in 10 subjects, to feed dietary fats thought to enhance upper gut CpFA production. The latter will be monitored through post-meal blood and urine CpFA concentration measurements, as well as concentration in the stool.

Sparking Gut Bacteria Production of Bioactive Xenolipids in Situ

Sparking Gut Bacteria Production of Bioactive Xenolipids in Situ

Condition
Dietary Fat Metabolism
Intervention / Treatment

-

Contacts and Locations

Sacramento

University of California, Davis School of Medicine, Sacramento, California, United States, 95817

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Men and women aged 18 to 50, with a Body Mass Index (BMI) categorized "normal" through "overweight" (18.5-29.9 kg/m2) and able to provide informed consent in English will be recruited to the study.
  • * - pregnancy or lactation
  • * allergy or aversion to any of the foods that will be studied and/or provided
  • * history of gastrointestinal disorders including ulcerative colitis, Crohn's disease, celiac sprue, hereditary non-polyposis colorectal cancer (HNPCC), familial adenomatous polyposis, pancreatic disease, or liver disease
  • * history of any metabolic diseases (including, but not limited to: diabetes mellitus, hyperlipidemia)
  • * previous gastrointestinal resection or bariatric surgery
  • * bleeding disorders that preclude blood draws
  • * history of kidney disease
  • * recent hospital admissions (past 6 months) for heart disease (MI/CVA or CHF) or other CVD/CAD conditions under physician guided therapy
  • * cancer under radiation or chemotherapy treatment that is active or within 6 months of treatment
  • * regular alcohol intake of \> 2 drinks/day (equivalent to 720 mL of beer, 240 mL of wine, or 90 mL of spirits) and unwilling to abstain during the run-in week and test day
  • * use of tobacco and/or marijuana, hookahs, e-cigarettes (e-cigs, vapes, etc.) and not willing to abstain during the run-in week and test day
  • * use of illicit drugs and not willing to abstain during the run-in week and test day
  • * BMI greater than 30 kg/m2 or below 18.5 kg/m2
  • * regular (daily to weekly) use of over the counter (OTC) weight-loss aids, anti-acids or anti-inflammatories, and unwilling or unable to stop taking during the run-in week and test day
  • * regular OTC dietary supplements that interfere with the test foods being studied including pills, chewables, liquids or powders for the following: fiber, fish oil (including cod liver oil), probiotics, and unwilling or unable to stop taking during the run-in week and test day
  • * oral or IV antibiotic use in the past 6 months (could defer participation until 6 months post-completion of course of antibiotics)
  • * seated blood pressure \>140/90 mmHg
  • * fasting clinical lab tests outside acceptable values as ascertained at the screening blood draw
  • * current use of specific prescription medication(s) that could impact gut physiology, gut microbiota, or other systems relevant to metabolism and fat PK
  • * inability to freely give informed consent in English

Ages Eligible for Study

18 Years to 50 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of California, Davis,

Sean H. Adams, PhD, PRINCIPAL_INVESTIGATOR, University of California, Davis

Study Record Dates

2025-05-31