COMPLETED

Predicting Local and Distant Recurrence in T1 Colorectal Cancer

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Tumor recurrence significantly affects survival rates following the local resection of submucosal colorectal cancers (T1 CRC). Despite this, there are currently no reliable biomarkers established to predict recurrence in T1 CRC. This study seeks to improve the prediction of recurrence-free survival in individuals who have survived T1 CRC.

Official Title

Predicting Recurrence After Curative-Intent Resection of T1 Colorectal Cancer With Transcriptomics

Quick Facts

Study Start:2023-03-15
Study Completion:2025-06-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:COMPLETED

Study ID

NCT06314971

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Stage I, pT1 colorectal cancer (TNM classification, 8th edition).
  2. * Received standard diagnostic, staging, and stage-specific curative-intent resection (endoscopic or surgical, as per local guidelines).
  3. * Confirmed cancer-free survivorship at the time of study inclusion.
  1. * Lack of informed consent.
  2. * Induction of neoadjuvant systemic therapy before colorectal cancer resection.
  3. * Synchronous colorectal and non-colorectal cancer diagnosed at or before surgery.

Contacts and Locations

Principal Investigator

Ajay Goel, PhD
PRINCIPAL_INVESTIGATOR
City of Hope Medical Center

Study Locations (Sites)

City of Hope Medical Center
Duarte, California, 91010
United States

Collaborators and Investigators

Sponsor: City of Hope Medical Center

  • Ajay Goel, PhD, PRINCIPAL_INVESTIGATOR, City of Hope Medical Center

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-03-15
Study Completion Date2025-06-30

Study Record Updates

Study Start Date2023-03-15
Study Completion Date2025-06-30

Terms related to this study

Keywords Provided by Researchers

  • Endoscopic Submucosal Dissection (ESD)
  • Endoscopic Submucosal Resection
  • Surgery
  • T1
  • Pathological T1 (pT1)
  • Messenger RNA
  • Micro RNA
  • Formalin-Fixed Paraffin Embedded
  • Tissue
  • Transcriptomics

Additional Relevant MeSH Terms

  • Colorectal Cancer
  • Colorectal Neoplasms
  • Colorectal Adenocarcinoma
  • Colorectal Cancer Stage I
  • Colorectal Neoplasms Malignant
  • Colorectal Cancer Recurrent