A Study of CBX 12 in Subjects With Platinum Resistant or Refractory Ovarian Cancer

Eligibility Criteria

• * Subjects must have histologically- or cytologically-diagnosed epithelial high-grade serous cancer of the ovary, fallopian tube cancer or primary peritoneum cancer that is refractory to prior therapy and must have platinum-resistant disease defined as:
• * Subjects who have received only 1 platinum-based chemotherapy regimen for at least 4 cycles of platinum must have disease progression on treatment or occurring ≤ 26 weeks after their last dose of platinum.
• * Patients who have progressed following a second course of a platinum based regimen.
• * Subjects may have up to 2 additional systemic regimens for advanced or metastatic disease. Maintenance regimens (e.g., with a PARP inhibitor or bevacizumab) are not considered separate regimens.
• * Age greater than or equal to 18 years at the time of signing the informed consent form (ICF).
• * Has measurable disease per RECIST 1.1.
• * Has provided written informed consent.
• * Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1.
• * Adequate liver, renal, hematologic, pulmonary and coagulation function.
• * Cytotoxic chemotherapy, biologic agent, investigational agent, or radiation therapy within 3 weeks prior to the first dose of CBX-12.
• * Subjects who are currently receiving any other anticancer or investigational agent(s).
• * Clinically significant intercurrent disease.
• * Active human immunodeficiency virus (HIV) infection.
• * Active hepatitis B or C infection.