Type 2 Diabetes and Blood Brain Barrier Improvement

Description

The majority of T2DM adults show thiamine (vitamin B1) deficiency which may contribute to impaired function. This study will examine patients with T2DM through brain MRI scans, cognition assessments, blood tests, and questionnaires. Our goal is to see if a thiamine treatment (taking vitamin B1 capsules) can improve function. Patients will be asked to come to UCLA two times three months apart and each visit will last about 2.5-3 hours.

Conditions

Type2diabetes

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Study Overview

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Study Details

Study overview

The majority of T2DM adults show thiamine (vitamin B1) deficiency which may contribute to impaired function. This study will examine patients with T2DM through brain MRI scans, cognition assessments, blood tests, and questionnaires. Our goal is to see if a thiamine treatment (taking vitamin B1 capsules) can improve function. Patients will be asked to come to UCLA two times three months apart and each visit will last about 2.5-3 hours.

Type 2 Diabetes Mellitus and Blood Brain Barrier Improvement - A Randomized Clinical Trial

Type 2 Diabetes and Blood Brain Barrier Improvement

Condition
Type2diabetes
Intervention / Treatment

-

Contacts and Locations

Los Angeles

UCLA, Los Angeles, California, United States, 90095

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Diagnosed T2DM
  • * Outpatient status
  • * Able to lay flat for imaging
  • * A previous history of stroke
  • * Current in-take of thiamine
  • * Known thiamine allergy
  • * Seizure disorder
  • * Head trauma
  • * Myocardial infarction
  • * Current pregnancy (if female)
  • * Diagnosed neuropsychiatric disorders (clinical depression, schizophrenia, manic-depression)
  • * Diagnosed dementia
  • * Sleep disordered breathing
  • * Airway or chest deformities that would interfere with breathing
  • * Chronic obstructive pulmonary disease
  • * Cystic fibrosis
  • * Presence of brain mass lesions
  • * Any history of drug abuse (e.g., cocaine, tobacco, or cannabis)
  • * Renal failure (requiring dialysis)
  • * All T2DM adults with metallic and electronic implants (phrenic or cardiac pacemakers; although some pacemakers and cardioverter defibrillators are safe at a low magnetic field, they are not safe at 3.0-Tesla scanner)
  • * Non-removable insulin pump/glucose sensor
  • * Braces
  • * Body weight more than 300 pounds (weight and height will be used to calculate BMI to determine if the patient will fit in the scanner and stay within parameters of size restrictions of MRI scanner table)
  • * Any other contraindications to MRI, such as claustrophobia, or metallic-based tattoos, as per MRI safety website suggestions, will also be excluded.

Ages Eligible for Study

40 Years to 65 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of California, Los Angeles,

Study Record Dates

2026-04