RECRUITING

tVNS During Motor Training in Older Adults

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this study is to learn about the effect of applying transcutaneous vagus nerve stimulation (tVNS) during motor training on motor learning in older adults. The main question it aims to answer is whether applying tVNS after successful motor trials (post-success tVNS) will facilitate the rate of motor learning. Participants will be randomly assigned to tVNS or sham group and receive tVNS or sham, respectively, at the outer ear during finger control training sessions. Finger control performance will be tested before and after the training sessions without outer ear stimulation.

Official Title

Pairing tVNS With Motor Skill Training in Older Adults

Quick Facts

Study Start:2025-05-27

Study Completion:2026-07-31

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT06323954

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:65 Years to 84 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:Yes

Standard Ages:OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* 65-84 years old across all races, genders, and ethnicities. * Right-handed * Physically and cognitively healthy	* Younger than 65 years old or older than 84 years old * Current or history of cardiac disease * Have an implanted device such as a neurostimulator or cochlear implant * Current or history of tympanic membrane perforation * Have a musculoskeletal issue that prevents hand function (e.g., arthritis) * Have a vision problem not corrected by glasses or contact lenses * Uncorrected auditory impairments * Had a stroke or lesion (including tumor) in the brain * Had a head injury or brain surgery * Suffer from frequent or severe headaches * Had a fainting spell or syncope * Have any metal in the head such as shrapnel, surgical clips, or fragments from welding or metal work * Have any implanted device such as cardiac pacemakers, medical pumps, or intracardiac lines * Had any brain-related conditions (i.e. multiple sclerosis, Parkinson, Alzheimer) * Had any illness that caused brain injury (i.e. meningitis, aneurysm, brain tumor) * Had any head trauma that was associated with a loss of consciousness or diagnosed as a concussion * Being treated for any psychiatric condition (i.e. depression, anxiety, PTSD, schizophrenia) * Suspected of pregnancy * Pregnant * Cognitive status issues as confirmed with the Mini-Mental State Exam (MMSE \<26) * Musculoskeletal condition or injury that would limit hand range of motion

Inclusion Criteria

Exclusion Criteria

* 65-84 years old across all races, genders, and ethnicities.
* Right-handed
* Physically and cognitively healthy

* Younger than 65 years old or older than 84 years old
* Current or history of cardiac disease
* Have an implanted device such as a neurostimulator or cochlear implant
* Current or history of tympanic membrane perforation
* Have a musculoskeletal issue that prevents hand function (e.g., arthritis)
* Have a vision problem not corrected by glasses or contact lenses
* Uncorrected auditory impairments
* Had a stroke or lesion (including tumor) in the brain
* Had a head injury or brain surgery
* Suffer from frequent or severe headaches
* Had a fainting spell or syncope
* Have any metal in the head such as shrapnel, surgical clips, or fragments from welding or metal work
* Have any implanted device such as cardiac pacemakers, medical pumps, or intracardiac lines
* Had any brain-related conditions (i.e. multiple sclerosis, Parkinson, Alzheimer)
* Had any illness that caused brain injury (i.e. meningitis, aneurysm, brain tumor)
* Had any head trauma that was associated with a loss of consciousness or diagnosed as a concussion
* Being treated for any psychiatric condition (i.e. depression, anxiety, PTSD, schizophrenia)
* Suspected of pregnancy
* Pregnant
* Cognitive status issues as confirmed with the Mini-Mental State Exam (MMSE \<26)
* Musculoskeletal condition or injury that would limit hand range of motion

Contacts and Locations

Study Contact

Minoru Shinohara, PhD

CONTACT

4048941030

shinohara@gatech.edu

Principal Investigator

Minoru Shinohara, PhD

PRINCIPAL_INVESTIGATOR

Georgia Institute of Technology

Study Locations (Sites)

Human Neuromuscular Physiology Lab

Atlanta, Georgia, 30332

United States

Collaborators and Investigators

Sponsor: Georgia Institute of Technology

Minoru Shinohara, PhD, PRINCIPAL_INVESTIGATOR, Georgia Institute of Technology

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-05-27

Study Completion Date2026-07-31

Study Record Updates

Study Start Date2025-05-27

Study Completion Date2026-07-31

Terms related to this study

Additional Relevant MeSH Terms

Older Adults