Thiamine Intervention and Coronary Artery Bypass Grafting

Description

The purpose of this study is to gain a better understanding of the association between brain changes and cognitive deficits in coronary heart disease (CHD) patients undergoing coronary artery bypass grafting (CABG) and whether a low-cost thiamine intervention can be used to reduce post-CABG cognitive issues in CHD subjects.

Conditions

Coronary Heart Disease, Coronary Artery Bypass Grafting

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Study Overview

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Study Details

Study overview

The purpose of this study is to gain a better understanding of the association between brain changes and cognitive deficits in coronary heart disease (CHD) patients undergoing coronary artery bypass grafting (CABG) and whether a low-cost thiamine intervention can be used to reduce post-CABG cognitive issues in CHD subjects.

Thiamine Intervention and Cognition in Older Adults Undergoing Coronary Artery Bypass Grafting - a Randomized Clinical Trial.

Thiamine Intervention and Coronary Artery Bypass Grafting

Condition
Coronary Heart Disease
Intervention / Treatment

-

Contacts and Locations

Los Angeles

UCLA, Los Angeles, California, United States, 90095

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Patients with Coronary Heart Disease (CHD) scheduled for Bypass Grafting (CABG)
  • * Thiamine deficiency before CABG
  • * European System for Cardiac Operative Risk Evaluation II (EuroSCORE II) \>1.5%
  • * Off-pump surgery
  • * Dementia at baseline \[Montreal Cognitive Assessment (MoCA) \<21 within 5 days before CABG\]
  • * Current in-take of thiamine
  • * Known thiamine allergy
  • * Uncontrolled blood glucose levels
  • * Unable to give consent due to illness
  • * History of hyperlactatemia
  • * Recent (within several years and/or up to the judgment of the PI/co-PIs) cerebral incidents (seizure or head trauma resulting in loss of consciousness and/or concussion)
  • * Stroke
  • * Diagnosed psychiatric diseases (clinical depression, schizophrenia, manic-depression)
  • * Patients with history of alcohol or substance abuse
  • * Acute or chronic infections (tuberculosis, hepatitis, or encephalopathy)
  • * Diagnosed neuro-degenerative diseases (Alzheimer's or Parkinson's disease)
  • * Chronic immunodeficiency (including HIV)
  • * Congenital brain deficits will also be excluded

Ages Eligible for Study

60 Years to 80 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of California, Los Angeles,

Rajesh Kumar, PhD, PRINCIPAL_INVESTIGATOR, University of California, Los Angeles

Study Record Dates

2025-09-29