Caffeine Use in the Management of Preterm Infants

Description

This study aims to assess whether extending the duration of caffeine therapy will help preterm infants achieve full oral feeding faster.

Conditions

Apnea of Prematurity

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Study Overview

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Study Details

Study overview

This study aims to assess whether extending the duration of caffeine therapy will help preterm infants achieve full oral feeding faster.

Caffeine Use in the Management of Preterm Infants

Caffeine Use in the Management of Preterm Infants

Condition
Apnea of Prematurity
Intervention / Treatment

-

Contacts and Locations

Orange

UC Irvine Medical Center, Orange, California, United States, 92868

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Equal to or greater than 34 weeks and 0 days corrected gestation at time of enrollment.
  • * Off respiratory support for at least 2 days (nasal canula oxygen, high flow nasal canula, continuous positive airway pressure (CPAP), mechanical ventilation).
  • * On caffeine and meet criteria to discontinue caffeine.
  • * No significant cardiopulmonary events for at least 5 days (apnea \> 20 seconds, apnea with heart rate (HR) \< 80 beats per minute (bpm), HR \< 80 bpm with desaturation \< 85% or color change).
  • * Infants with critical congenital heart disease.
  • * Infants with neuromuscular conditions affecting respiration.
  • * Infants with overt brain injury (i.e. severe Grade 3-4 intraventricular hemorrhage, cystic periventricular leukomalacia) that may affect oral feeding.
  • * Infants with major genetic disorders.
  • * Infants with anatomic anomalies that will hinder oral feeding.
  • * Infants who have already progressed to Step 3 (of 5) of our institution's oral feeding protocol (oral feeds 4 times per day).
  • * Infants who develop necrotizing enterocolitis after enrollment.
  • * Failure to obtain consent or declined by parents.

Ages Eligible for Study

1 Week to 40 Weeks

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of California, Irvine,

Cherry Uy, MD, PRINCIPAL_INVESTIGATOR, UC Irvine

Study Record Dates

2026-12-31