COMPLETED

Predicting Language and Literacy Growth in Children With ASD Using Statistical Learning

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this observational study is to test a reciprocal relationship between statistical learning and the development of language and literacy in first-graders with autism and their non-autistic peers. The main questions it aims to answer are: 1. whether children's statistical learning abilities can predict their long-term improvement of language and literacy skills in school; 2. how children's brains automatically learn patterns from speech and prints; 3. whether children's learning in the lab reflects the language patterns they have learned over the years from their native language. First-grade students will participate in the study twice across three months. During Time 1, children will complete * a battery of language, reading, and cognitive assessments * a series of computer-based statistical learning games both inside and outside of functional MRI scanner. During Time 2, children will complete a battery of language and reading assessments to detect the growth in three months. Researchers will compare the autistic and the non-autistic groups to see if statistical learning plays a similar or different role in predicting children's language and literacy growth.

Official Title

Predicting Language and Literacy Growth in Children With ASD Using Statistical Learning

Quick Facts

Study Start:2024-01-13
Study Completion:2025-08-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:COMPLETED

Study ID

NCT06332144

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:72 Months to 90 Months
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:CHILD
Inclusion CriteriaExclusion Criteria
  1. * current first grader (6;0 - 7;6)
  2. * Geographically located within the Greater Boston Metropolitan Area
  3. * Native English speakers
  4. * Normal hearing
  5. * Normal or corrected vision
  6. * Children with a professional diagnosis of autism according to expert clinical judgment
  7. * Capable of speaking sentences with three or more words
  8. * Social Communication Parent Questionnaire score \> 15
  9. * Autism diagnosis confirmed by ADOS
  10. * Neurotypical: with no known cognitive, neurological, or psychiatric disorders
  11. * Social Communication Parent Questionnaire score \< 11
  12. * Receive a score within 1 SD of the population mean for age on all assessments.
  1. * non-native speakers of English
  2. * More than 30 hours of exposure to a language other than English per week
  3. * history of brain injuries and head injuries
  4. * intellectual disability, mutism, motor delay, or developmental coordination disorder
  5. * metal in body
  6. * claustrophobic
  7. * history of prior neurosurgical procedure
  8. * substance abuse
  9. * signs of increased intracranial pressure

Contacts and Locations

Principal Investigator

Zhenghan Qi, MD/PhD
PRINCIPAL_INVESTIGATOR
Northeastern University

Study Locations (Sites)

Northeastern University
Boston, Massachusetts, 02115
United States
Boston University
Boston, Massachusetts, 02215
United States

Collaborators and Investigators

Sponsor: Northeastern University

  • Zhenghan Qi, MD/PhD, PRINCIPAL_INVESTIGATOR, Northeastern University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-01-13
Study Completion Date2025-08-31

Study Record Updates

Study Start Date2024-01-13
Study Completion Date2025-08-31

Terms related to this study

Keywords Provided by Researchers

  • Statistical Learning
  • Implicit Learning
  • Neuroimaging
  • Autism Spectrum Disorder
  • Language Development
  • Reading Development
  • fMRI

Additional Relevant MeSH Terms

  • Autism Spectrum Disorder
  • Language Development
  • Literacy