Interoceptive Mechanisms of Body Image Disturbance in Anorexia Nervosa

Description

The proposed study utilizes a randomized experimental therapeutics design to test a mechanistic framework linking interoceptive processing and disturbed body image, with the purpose of informing the development of future therapies for body image dissatisfaction in anorexia nervosa (AN). A sample of 102 participants will be recruited from the Laureate Eating Disorder Program (LEDP). After being randomized, participants will all receive a one-hour session of acceptance- and mindfulness-based training with a therapist (the introduction session). They will then receive either the interoceptively focused treatment (IFT) or exteroceptively focused treatment (EFT) condition based on randomization. In the IFT condition participants will engage in floatation-REST (Reduced Environmental Stimulation Therapy) while practicing acceptance and mindfulness-based principles. The EFT condition is an exteroceptive intervention in which participants will be asked to view pre-recorded videos of acceptance and mindfulness-based skills to aid in the practice of these skills. Each condition will consist of one introduction session and three experimental sessions. All participants will then return for follow-up measures. Assessed outcomes will include acute changes in body image disturbance (BID) and interoception. Further, longitudinal intervention effects on self-reported eating disorder symptoms, body image dissatisfaction, and interoception; behavioral measures of interoception and body image dissatisfaction; and resting state and interoceptive functioning during functional magnetic resonance imaging (fMRI) will be explored.

Conditions

Anorexia Nervosa, Body Image Disturbance, Interoception

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Study Details

Study overview

The proposed study utilizes a randomized experimental therapeutics design to test a mechanistic framework linking interoceptive processing and disturbed body image, with the purpose of informing the development of future therapies for body image dissatisfaction in anorexia nervosa (AN). A sample of 102 participants will be recruited from the Laureate Eating Disorder Program (LEDP). After being randomized, participants will all receive a one-hour session of acceptance- and mindfulness-based training with a therapist (the introduction session). They will then receive either the interoceptively focused treatment (IFT) or exteroceptively focused treatment (EFT) condition based on randomization. In the IFT condition participants will engage in floatation-REST (Reduced Environmental Stimulation Therapy) while practicing acceptance and mindfulness-based principles. The EFT condition is an exteroceptive intervention in which participants will be asked to view pre-recorded videos of acceptance and mindfulness-based skills to aid in the practice of these skills. Each condition will consist of one introduction session and three experimental sessions. All participants will then return for follow-up measures. Assessed outcomes will include acute changes in body image disturbance (BID) and interoception. Further, longitudinal intervention effects on self-reported eating disorder symptoms, body image dissatisfaction, and interoception; behavioral measures of interoception and body image dissatisfaction; and resting state and interoceptive functioning during functional magnetic resonance imaging (fMRI) will be explored.

Interoceptive Mechanisms of Body Image Disturbance in Anorexia Nervosa

Interoceptive Mechanisms of Body Image Disturbance in Anorexia Nervosa

Condition
Anorexia Nervosa
Intervention / Treatment

-

Contacts and Locations

Tulsa

Laureate Institute for Brain Research, Tulsa, Oklahoma, United States, 74136

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Primary diagnosis of anorexia nervosa
  • 2. Photographic Figure Rating Scale (PFRS) body dissatisfaction score greater than or equal to 1
  • 3. Eating Disorder Examination Questionnaire (EDE-Q6) Shape Concern Subscale score greater than or equal to 3
  • 4. Weight restored to body mass index (BMI) greater than or equal to 17.5
  • 5. No current evidence of orthostatic hypotension
  • 6. Clinical status transition from acute to residential status
  • 7. No new psychiatric medications in the week prior to randomization
  • 8. Female sex assigned at birth
  • 9. Ages 15 to 40 years
  • 10. Independently ambulatory
  • 11. Ability to lay flat comfortably
  • 12. English proficiency
  • 13. Willingness and ability to participate in study procedures
  • 14. Provision of informed consent (parent consent and minor assent if less than 18 years of age).
  • 1. Active suicidal ideation with plan and intent
  • 2. Active cutting or skin lacerating behaviors
  • 3. Pregnancy as defined by urine screening
  • 4. Acute intoxication as indicated by urine drug screen or breathalyzer
  • 5. Orthostatic hypotension (defined as a drop of ≥ 20 mmHg in systolic blood pressure (SBP) or a drop of ≥ 10 mm Hg in diastolic blood pressure (DBP) when measured shortly after transitioning from lying down to standing)
  • 6. Seizure reported within the previous 12 months
  • 7. Co-morbid diagnoses of Diagnostic and Statistical Manual of Mental Disorders, 5th ed. (DSM-5) bipolar disorder, schizophrenia, or other psychosis spectrum disorder
  • 8. Systolic blood pressure \> 160 mmHg
  • 9. Diastolic blood pressure \>100 mmHg
  • 10. Resting heart rate \<50 beats per minute.

Ages Eligible for Study

15 Years to 40 Years

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

Laureate Institute for Brain Research, Inc.,

Emily M Choquette, PhD, PRINCIPAL_INVESTIGATOR, Laureate Institute for Brain Research

Study Record Dates

2028-12