RECRUITING

4-aminopyridine for Skin Wound Healing

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Many patients suffer from chronic non-healing wounds as well as acute wounds. There is a need to develop treatments to accelerate and improve healing of chronic and acute wounds. More research is needed to evaluate the role of 4-aminopyridine (4-AP), a promising new agent with an excellent safety profile, on wound healing. The investigational treatment will be used to evaluate the role of (4-AP) on the treatment of wounds to accelerate wound healing in healthy adults. The purpose of this study is to evaluate the role of 4-AP on the treatment of wounds to accelerate healing. The investigational treatment will be used to test the hypothesis that 4-AP can speed wound healing.

Official Title

4-aminopyridine for Skin Wound Healing

Quick Facts

Study Start:2025-08
Study Completion:2028-03
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06333171

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 70 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Otherwise healthy adult patients without skin conditions effecting the skin of the axilla or upper inner arm.
  2. * Cognitive ability to evaluate wound healing, report sensory and motor deficit during examination.
  3. * Eligible for standard of care plan for wound closure by secondary intention (normal healing without intervention).
  4. * Adults subject aged 18-70
  5. * Ability to give written informed consent.
  6. * Capable of safely coming in for follow up visits on all scheduled appointments.
  1. * History of multiple sclerosis, stroke or any other diagnosed neurological disorder
  2. * History of hypersensitivity to AMPYRA® or 4-aminopyridine
  3. * Current use of aminopyridine medications, including other compounded 4-AP
  4. * Suspected renal impairment based on the Choyke questionnaire.
  5. * History of difficult compliance with timely follow up
  6. * Patients outside the age range
  7. * Unable to provide informed consent.
  8. * Patients with a known history of a seizure disorder (4-AP overdose can, in selected cases, result in limited seizure activity).
  9. * Patients with a concomitant traumatic brain injury.
  10. * Patients unable to communicate.
  11. * Patients unwilling to complete the study requirements.
  12. * Patients currently taking organic cat-ion transporter 2 (OCT2) inhibitors, e.g. Cimetidine.
  13. * Pregnancy, breastfeeding or incarcerated individuals.
  14. * Non-English speaking
  15. * Patients unable or unwilling to take calibrated (with gauge) photographs of their wounds

Contacts and Locations

Study Contact

Andrea Horne
CONTACT
520-626-6456
ahh@arizona.edu

Principal Investigator

John Elfar, MD
PRINCIPAL_INVESTIGATOR
University of Arizona

Study Locations (Sites)

University of Arizona
Tucson, Arizona, 85724
United States

Collaborators and Investigators

Sponsor: John Elfar

  • John Elfar, MD, PRINCIPAL_INVESTIGATOR, University of Arizona

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-08
Study Completion Date2028-03

Study Record Updates

Study Start Date2025-08
Study Completion Date2028-03

Terms related to this study

Keywords Provided by Researchers

  • 4 aminopyridine
  • wound healing

Additional Relevant MeSH Terms

  • Wounds
  • Wound of Skin
  • Wound Heal
  • Wounds and Injuries