COMPLETED

ALIGN: Aligning Medications With What Matters Most (Demonstration)

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this clinical trial is to test the effectiveness of a pharmacist-led, primary care-based de-prescribing intervention for people living with dementia (PLWD) and the person's care partners. The intervention consists of the following strategies: 1) a de-prescribing educational brochure designed to activate the patient and care partner; 2) a single telehealth visit in which an embedded clinical pharmacist discusses the benefits and harms of the patient's medications with the patient and care partner in the context of the person's goals and preferences; and 3) pharmacist-PCP communication in which the pharmacist provides tailored de-prescribing recommendations designed to be useful and actionable for the PCP. The investigators will compare the intervention group with the waitlist control group to see if there is a difference in the primary outcome, the proportion of patients who deprescribe at least one medication by 3 months.

Official Title

Demonstration of ALIGN: Aligning Medications With What Matters Most

Quick Facts

Study Start:2024-05-07
Study Completion:2025-10-18
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:COMPLETED

Study ID

NCT06335953

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:65 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Age ≥65 years
  2. * Diagnosis of dementia from International Classification of Diseases (ICD-10) visit codes or from the EHR problem list
  3. * Five or more medications
  4. * Only active patients, defined as having \>1 visit to the primary care clinic within the past year will be included
  5. * Family or other companions \>21 years old who regularly help the patient manage medications.
  1. * As the pragmatic trial will be based on primary care, individuals residing in long-term care facilities or enrolled in hospice will be excluded.
  2. * Participants must hear well enough to communicate by telephone in English.

Contacts and Locations

Principal Investigator

Ariel Green, MD, MPH, PhD
PRINCIPAL_INVESTIGATOR
Johns Hopkins University

Study Locations (Sites)

Johns Hopkins Community Physicians
Baltimore, Maryland, 21209
United States

Collaborators and Investigators

Sponsor: Johns Hopkins University

  • Ariel Green, MD, MPH, PhD, PRINCIPAL_INVESTIGATOR, Johns Hopkins University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-05-07
Study Completion Date2025-10-18

Study Record Updates

Study Start Date2024-05-07
Study Completion Date2025-10-18

Terms related to this study

Keywords Provided by Researchers

  • Deprescribing

Additional Relevant MeSH Terms

  • Polypharmacy
  • Alzheimer's Disease and Related Dementias
  • Mild Cognitive Impairment