ALIGN: Aligning Medications With What Matters Most (Demonstration)

Description

The goal of this clinical trial is to test the effectiveness of a pharmacist-led, primary care-based de-prescribing intervention for people living with dementia (PLWD) and the person's care partners. The intervention consists of the following strategies: 1) a de-prescribing educational brochure designed to activate the patient and care partner; 2) a single telehealth visit in which an embedded clinical pharmacist discusses the benefits and harms of the patient's medications with the patient and care partner in the context of the person's goals and preferences; and 3) pharmacist-PCP communication in which the pharmacist provides tailored de-prescribing recommendations designed to be useful and actionable for the PCP. The investigators will compare the intervention group with the waitlist control group to see if there is a difference in the primary outcome, the proportion of patients who deprescribe at least one medication by 3 months.

Conditions

Polypharmacy, Alzheimer's Disease and Related Dementias, Mild Cognitive Impairment

Talk to us

Study Overview

On this page

Study Details

Study overview

The goal of this clinical trial is to test the effectiveness of a pharmacist-led, primary care-based de-prescribing intervention for people living with dementia (PLWD) and the person's care partners. The intervention consists of the following strategies: 1) a de-prescribing educational brochure designed to activate the patient and care partner; 2) a single telehealth visit in which an embedded clinical pharmacist discusses the benefits and harms of the patient's medications with the patient and care partner in the context of the person's goals and preferences; and 3) pharmacist-PCP communication in which the pharmacist provides tailored de-prescribing recommendations designed to be useful and actionable for the PCP. The investigators will compare the intervention group with the waitlist control group to see if there is a difference in the primary outcome, the proportion of patients who deprescribe at least one medication by 3 months.

Demonstration of ALIGN: Aligning Medications With What Matters Most

ALIGN: Aligning Medications With What Matters Most (Demonstration)

Condition
Polypharmacy
Intervention / Treatment

-

Contacts and Locations

Baltimore

Johns Hopkins Community Physicians, Baltimore, Maryland, United States, 21209

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age ≥65 years
  • * Diagnosis of dementia from International Classification of Diseases (ICD-10) visit codes or from the EHR problem list
  • * Five or more medications
  • * Only active patients, defined as having \>1 visit to the primary care clinic within the past year will be included
  • * Family or other companions \>21 years old who regularly help the patient manage medications.
  • * As the pragmatic trial will be based on primary care, individuals residing in long-term care facilities or enrolled in hospice will be excluded.
  • * Participants must hear well enough to communicate by telephone in English.

Ages Eligible for Study

65 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Johns Hopkins University,

Ariel Green, MD, MPH, PhD, PRINCIPAL_INVESTIGATOR, Johns Hopkins University

Study Record Dates

2025-05