Tau Biomarkers in Late-onset Psychosis (LOP)

Eligibility Criteria

• 1. Male or female, aged 65-85 years.
• 2. Diagnosis of late-onset non-affective primary psychotic disorder consistent with either very late-onset schizophrenia-like psychosis (VLOSP, International Late-Onset Schizophrenia Group consensus criteria, Howard et al., 2000) or delusional disorder (DSM-5 criteria)
• 3. Caregiver available to provide collateral history and participation in informant-based ratings (NPI,CDR)
• 4. Clinical Dementia Rating (CDR) score of 0 or 0.5.
• 5. Mini-Mental State Examination (MMSE) score ≥ 24 and at the screening visit.
• 6. Normal memory function (to rule-out mild cognitive impairment, MCI) documented by scoring within 1.5 SD range in education adjusted norms of the Logical Memory II subscale
• 7. Ability to hear 500, 1000 and 1500 Hz bilaterally on a hearing evaluation (hearing aids permitted).
• 1. Participants with affective and psychotic disorders including bipolar disorder, schizoaffective disorder, active major depression; insulin dependent type 2 diabetes; a history of CVD; a history of epilepsy; a history of TBI with greater than 15 minutes of loss of consciousness; a movement disorder including Parkinson's disease; stroke; autoimmune disease affecting the CNS; substance abuse disorder; or active delirium/encephalopathy.
• 2. Evidence of a clinically relevant neurological disorder
• 3. Modified Hachinski ischemia score of more than 4.
• 4. History of alcoholism or drug dependency/abuse within the last 5 years before screening.
• 5. Presence of metal implants such as pacemakers, ear implants, internal bullet fragments or shrapnel.
• 6. Inability to lie flat for 1 hour approximately.
• 7. Hearing impairment as evidenced by the inability to hear 500, 1000 and 1500 Hz bilaterally on a hearing evaluation. Subjects with hearing aids will be allowed to participate if they meet minimum hearing requirements.