Structured Personalized Oxygen and Supportive Therapies for Dyspnea in Oncology

Eligibility Criteria

• * Diagnosis of advanced cancer (metastatic, locally advanced, recurrent, or incurable).
• * Age 18 or older.
• * Admitted to a medical floor.
• * Dyspnea intensity at rest of at least 4 on a 0-10-point NRS (where 0 = none, 10 = worst).
• * Speak English or Spanish.
• * Hemodynamic instability requiring active Merit Team or ICU team involvement.
• * Delirium as per clinical team's assessment in the Electronic Health Record (EHR).
• * Severe hypoxemia (SpO2 \< 90% despite supplemental oxygen of up to 6 L/min).
• * Continuous positive airway pressure (CPAP) use for obstructive sleep apnea \>10 hours a day.
• * Respiratory failure necessitating mechanical ventilation (i.e., HFNC or NIV), and planned thoracentesis within 72 hours of enrollment.
• * Patients with known pregnancy.