Inspiratory Muscle Training on The Severity of Exercise-Induced Bronchoconstriction and Time-Trial Performance (IMT_EIB)

Description

Due to the lack of studies examining the impact of inspiratory muscle training (IMT) on the severity of exercise-induced bronchoconstriction (EIB) and exercise performance, the specific aim of this study is to assess the efficacy of flow-resistive IMT on EIB severity and symptoms, short-acting beta-2-agonist medication use, operating lung volumes, respiratory and limb locomotor muscle deoxygenation during constant-load cycling exercise, exertional dyspnea, and cycling time-trial performance.

Conditions

Exercise Induced Bronchospasm, Exercise Induced Asthma

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Study Overview

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Study Details

Study overview

Due to the lack of studies examining the impact of inspiratory muscle training (IMT) on the severity of exercise-induced bronchoconstriction (EIB) and exercise performance, the specific aim of this study is to assess the efficacy of flow-resistive IMT on EIB severity and symptoms, short-acting beta-2-agonist medication use, operating lung volumes, respiratory and limb locomotor muscle deoxygenation during constant-load cycling exercise, exertional dyspnea, and cycling time-trial performance.

Effect of Flow-Resistive Inspiratory Muscle Training on The Severity of Exercise-Induced Bronchoconstriction and Cycling Time-Trial Performance

Inspiratory Muscle Training on The Severity of Exercise-Induced Bronchoconstriction and Time-Trial Performance (IMT_EIB)

Condition
Exercise Induced Bronchospasm
Intervention / Treatment

-

Contacts and Locations

Bloomington

School of Public Health-Bloomington, Bloomington, Indiana, United States, 47405

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Male and female, between the ages of 18 to 35 years.
  • * Required to be a competitive recreational or college athlete and have at least 1-2 years of cycling or biking experience.
  • * Body Mass Index (BMI) of 18.5 to 28 kg/m\^2
  • * Considered "moderately to highly active" by the International Physical Activity Questionnaire (IPAQ).
  • * Have clinically treated mild to moderate persistent asthma and/or exercise-induced bronchoconstriction (EIB), with a resting forced expiratory volume in 1 second (FEV1) \> 65% of predicted.
  • * A ≥ 10% drop in FEV1 after eucapnic voluntary hyperpnea (EVH).
  • * Prescribed short-acting β2-agonists (SABAs) by a physician.
  • * Comfortable not taking SABA before experimental visits.
  • * History of smoking or recreational smoking, cardiovascular disease, renal disease, neurological disease, and metabolic disease.
  • * Currently taking asthma maintenance medications (e.g., corticosteroids and leukotriene modifiers)
  • * Any injuries in the past 6 months.
  • * Taking selective serotonin reuptake inhibitors (SSRI)'s (antidepressants and anxiety medication), attention-deficit hyperactivity disorder (ADHD) medication, and chronically consume pain medication (Aleve, Tylenol, cannabidiol (CBD), etc.).
  • * Has had or is positive for COVID-19.
  • * Resting blood pressure of \> 130 mmHg systolic or 90 mmHg diastolic.
  • * Resting Pulse rate of \> 100 bpm.
  • * Regularly consuming fish oil supplements or eating more then one fish meal per week

Ages Eligible for Study

18 Years to 35 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Indiana University,

Tim Mickleborough, Ph.D., PRINCIPAL_INVESTIGATOR, Indiana University

Study Record Dates

2025-08