RECRUITING

An Exosome-Based Liquid Biopsy for the Differential Diagnosis of Primary Liver Cancer

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

It is sometimes difficult to precisely understand whether a primary liver cancer is a hepatocellular carcinoma or a cholangiocarcinoma. The researchers will develop and validate a liquid biopsy, based on exosomal content analysis and powered by machine learning, to help clinicians differentiate these two cancers before surgery.

Official Title

An Exosome-Based Liquid Biopsy for the Differential Diagnosis of Primary Liver Cancer

Quick Facts

Study Start:2024-03-15
Study Completion:2025-03-15
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06342414

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * A histologically confirmed diagnosis of hepatocellular carcinoma
  2. * A histologically confirmed diagnosis of intrahepatic cholangiocarcinoma
  3. * Received standard diagnostic and staging procedures as per local guidelines
  4. * Availability of at least one blood-derived sample, drawn before receiving any curative-intent treatment
  1. * Lack of or inability to provide informed consent
  2. * Synchronous hepatocellular carcinoma and intrahepatic cholangiocarcinoma
  3. * Primary liver cancer other than hepatocellular carcinoma or intrahepatic cholangiocarcinoma
  4. * Secondary liver cancer

Contacts and Locations

Study Contact

Ajay Goel, PhD
CONTACT
6262183452
AJGOEL@COH.ORG

Principal Investigator

Ajay Goel, PhD
PRINCIPAL_INVESTIGATOR
City of Hope Medical Center

Study Locations (Sites)

City of Hope Medical Center
Duarte, California, 91010
United States

Collaborators and Investigators

Sponsor: City of Hope Medical Center

  • Ajay Goel, PhD, PRINCIPAL_INVESTIGATOR, City of Hope Medical Center

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-03-15
Study Completion Date2025-03-15

Study Record Updates

Study Start Date2024-03-15
Study Completion Date2025-03-15

Terms related to this study

Keywords Provided by Researchers

  • Exosome
  • micro RNA
  • Differential Diagnosis

Additional Relevant MeSH Terms

  • Hepatocellular Carcinoma
  • Intrahepatic Cholangiocarcinoma
  • Cholangiocarcinoma
  • Primary Liver Cancer
  • Primary Liver Carcinoma
  • Hepatic Cancer
  • Hepatic Carcinoma