An Exosome-Based Liquid Biopsy for the Differential Diagnosis of Primary Liver Cancer

Description

It is sometimes difficult to precisely understand whether a primary liver cancer is a hepatocellular carcinoma or a cholangiocarcinoma. The researchers will develop and validate a liquid biopsy, based on exosomal content analysis and powered by machine learning, to help clinicians differentiate these two cancers before surgery.

Conditions

Hepatocellular Carcinoma, Intrahepatic Cholangiocarcinoma, Cholangiocarcinoma, Primary Liver Cancer, Primary Liver Carcinoma, Hepatic Cancer, Hepatic Carcinoma

Study Overview

Study Details

Study overview

It is sometimes difficult to precisely understand whether a primary liver cancer is a hepatocellular carcinoma or a cholangiocarcinoma. The researchers will develop and validate a liquid biopsy, based on exosomal content analysis and powered by machine learning, to help clinicians differentiate these two cancers before surgery.

An Exosome-Based Liquid Biopsy for the Differential Diagnosis of Primary Liver Cancer

An Exosome-Based Liquid Biopsy for the Differential Diagnosis of Primary Liver Cancer

Condition
Hepatocellular Carcinoma
Intervention / Treatment

-

Contacts and Locations

Duarte

City of Hope Medical Center, Duarte, California, United States, 91010

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * A histologically confirmed diagnosis of hepatocellular carcinoma
  • * A histologically confirmed diagnosis of intrahepatic cholangiocarcinoma
  • * Received standard diagnostic and staging procedures as per local guidelines
  • * Availability of at least one blood-derived sample, drawn before receiving any curative-intent treatment
  • * Lack of or inability to provide informed consent
  • * Synchronous hepatocellular carcinoma and intrahepatic cholangiocarcinoma
  • * Primary liver cancer other than hepatocellular carcinoma or intrahepatic cholangiocarcinoma
  • * Secondary liver cancer

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

City of Hope Medical Center,

Ajay Goel, PhD, PRINCIPAL_INVESTIGATOR, City of Hope Medical Center

Study Record Dates

2025-03-15