Detecting Mild Autonomous Cortisol Secretion in Patients with Adrenal Incidentaloma

Description

The aim of the proposed study is to estimate the incidence of Mild Autonomous Cortisol Secretion (MACS) in patients with Adrenal Incidentaloma (AI) and evaluate the available diagnostic tests to determine the most sensitive and specific combination of tests for assessing MACS from adrenal adenoma for prediction of the phenotype associated with cortisol excess. As well as following the patients for 4 years and see if anything changes.

Conditions

Mild Autonomous Cortisol Secretion (MACS)

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Study Overview

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Study Details

Study overview

The aim of the proposed study is to estimate the incidence of Mild Autonomous Cortisol Secretion (MACS) in patients with Adrenal Incidentaloma (AI) and evaluate the available diagnostic tests to determine the most sensitive and specific combination of tests for assessing MACS from adrenal adenoma for prediction of the phenotype associated with cortisol excess. As well as following the patients for 4 years and see if anything changes.

Detecting Mild Autonomous Cortisol Secretion in Patients with Adrenal Incidentaloma

Detecting Mild Autonomous Cortisol Secretion in Patients with Adrenal Incidentaloma

Condition
Mild Autonomous Cortisol Secretion (MACS)
Intervention / Treatment

-

Contacts and Locations

Cleveland

The Cleveland Clinic Foundation, Cleveland, Ohio, United States, 44195

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Patients ages 18 years and older.
  • 2. Presence of adrenal incidentaloma by cat scan (CT) or magnetic resonance imaging (MRI) examination.
  • 3. 1-mg Dexamethasone suppression test cortisol ≤ 5 μg/dL with adequate dexamethasone level.
  • 1. 1-mg Dexamethasone suppression test cortisol \> 5 μg/dL with adequate dexamethasone level. Patients who fail to suppress below this level will be considered to have Cushing's syndrome and will be referred for appropriate treatment.
  • 2. Current or recent (3 months) history of use of glucocorticoid medication (including joint injections of steroids).
  • 3. History of uncontrolled hypertension or history of hypertension with more than 2 medications.
  • 4. History of uncontrolled type 2 Diabetes Mellitus or history of diabetes mellitus with A1c\>7.5.
  • 5. Known History of osteoporosis
  • 6. Documented Clinical Cushing's disease.
  • 7. Clinical suspicion of adrenal carcinoma.
  • 8. History of alcohol abuse/dependence.
  • 9. History of cirrhosis of liver.
  • 10. History of hepatitis B or C infection regardless of treatment.
  • 11. History of type 1 diabetes.
  • 12. History of hemochromatosis.
  • 13. History of autoimmune hepatitis.
  • 14. History of Wilson's disease.

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

The Cleveland Clinic,

Ricardo Correa, MD, PRINCIPAL_INVESTIGATOR, The Cleveland Clinic

Study Record Dates

2030-12-31