NeuroControl of Nicotine Dependence

Description

The purpose of the study is to examine the effects of continuous theta burst stimulation (cTBS) on different forms of cognitive control in adults who smoke cigarettes, and to determine if the location where cTBS is delivered may help smokers reduce or quit smoking. Participation in the study will take 3-weeks over 4 visits, with a total time commitment of approximately 12 hours.

Conditions

Nicotine Dependence

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Study Overview

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Study Details

Study overview

The purpose of the study is to examine the effects of continuous theta burst stimulation (cTBS) on different forms of cognitive control in adults who smoke cigarettes, and to determine if the location where cTBS is delivered may help smokers reduce or quit smoking. Participation in the study will take 3-weeks over 4 visits, with a total time commitment of approximately 12 hours.

Neuronavigated Non-invasive Brain Stimulation for Nicotine Dependence.

NeuroControl of Nicotine Dependence

Condition
Nicotine Dependence
Intervention / Treatment

-

Contacts and Locations

Columbia

Health Neuroscience Center, Columbia, Missouri, United States, 65203

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Nicotine Dependence as measured by: Smoke ≥ 8 cigarettes/day for ≥ 2 yrs, expired carbon monoxide (CO) concentration of ≥ 10 ppm, positive urine cotinine test and FTND score ≥ 3 Or ≥ 15 uses of electronic cigarette/day for ≥ 1 year, positive urine cotinine test, and PS-ECDI score ≥ 3
  • 2. English Fluency
  • 3. Functional Vision (with corrective lenses as needed)
  • 1. Use of psychotropic and antiepileptic medications in the last month
  • 2. Presence of an untreated illness or serious medical condition
  • 3. History of major neurological illness
  • 4. Contraindication to TMS (history of neurological disorder or seizure, increased intracranial pressure, brain surgery, or head trauma with loss of consciousness for \>15 min., implanted electronic device, metal in the head) or MRI.
  • 5. Any use of substances that lower seizure threshold.
  • 6. Current or past psychosis
  • 7. Electroconvulsive therapy in the past 6 months
  • 8. Unstable cardiac disease or hypertension, severe renal or liver insufficiency, or sleep apnea
  • 9. BAC greater than 0.0.
  • 10. Positive urine pregnancy test
  • 11. Any other concern that in the investigator's opinion would impact participant safety, study instruction compliance, or confound the interpretation of the study results.

Ages Eligible for Study

18 Years to 60 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Missouri-Columbia,

Study Record Dates

2030-04-30