RECRUITING

Confirmatory Efficacy Trial of Attention Bias Modification for Depression

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this clinical trial is to compare the efficacy of two related, but different ABM (Attention Biased Modification) treatments for depression in adults with elevated symptoms of depression. The main aims are: * Aim 1:examine whether gamified ABM leads to greater change in the primary and secondary outcomes than sham ABM * Aim 1: establish that gamified ABM is at least as effective as traditional ABM. * Aim 2: identify moderators of ABM efficacy and mechanisms responsible for its efficacy. * Aim 3: Identify the durability of ABM on depression symptoms during short-term follow-up Participants will complete self-report questionnaires, complete eye-tracking tasks, and be clinically assessed through interviews by clinician researchers. If there is a comparison group: Researchers will compare sham, traditional, and gamified treatment groups to see if they moderate symptoms of depression.

Official Title

Confirmatory Efficacy Trial of a Traditional vs. Gamified Attention Bias Modification for Depression

Quick Facts

Study Start:2024-05-01
Study Completion:2028-05-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06361095

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 70 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Provided informed consent
  2. * Fluent in English
  3. * Scored 13 or greater on the QIDS-SR at the baseline assessment
  4. * Between the ages of 18 to 70
  5. * Have had no changes in medication and dosage in the past 12 weeks (if currently on antidepressant medication)
  1. * Reported suicidal behavior or significant suicidal ideation within the past six months using the Columbia-Suicide Severity Rating Scale (C-SSRS)
  2. * Met criteria for current or past bipolar or psychotic disorders
  3. * Current (i.e., within the past 12 months) substance use disorders of moderate or greater severity on the Mini International Neuropsychiatric Interview (MINI)
  4. * Currently taking opioid analgesics or systemic corticosteroid use as these medications
  5. * Currently receiving psychotherapy

Contacts and Locations

Study Contact

Christopher G Beevers, PhD
CONTACT
5124717557
beevers@utexas.edu

Principal Investigator

Christopher G Beevers, PhD
PRINCIPAL_INVESTIGATOR
UT Austin

Study Locations (Sites)

Institute for Mental Health Research
Austin, Texas, 78705
United States

Collaborators and Investigators

Sponsor: University of Texas at Austin

  • Christopher G Beevers, PhD, PRINCIPAL_INVESTIGATOR, UT Austin

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-05-01
Study Completion Date2028-05-01

Study Record Updates

Study Start Date2024-05-01
Study Completion Date2028-05-01

Terms related to this study

Keywords Provided by Researchers

  • depression treatment
  • attention bias modification
  • digital mental health treatment

Additional Relevant MeSH Terms

  • Depression