A Study of I-DXd in Combination With Atezolizumab With or Without Carboplatin as First-Line Induction or Maintenance in Subjects With Extensive Stage-Small Cell Lung Cancer (IDeate-Lung03)

Description

This study is designed to evaluate the safety and efficacy of ifinatamab deruxtecan (I-DXd) in combination with immune checkpoint inhibitor (ICI) atezolizumab with or without carboplatin in participants with extensive stage-small cell lung cancer (ES-SCLC) in the first-line (1L) setting.

Conditions

Extensive Stage-small Cell Lung Cancer

Study Overview

Study Details

Study overview

This study is designed to evaluate the safety and efficacy of ifinatamab deruxtecan (I-DXd) in combination with immune checkpoint inhibitor (ICI) atezolizumab with or without carboplatin in participants with extensive stage-small cell lung cancer (ES-SCLC) in the first-line (1L) setting.

A Phase 1b/2, Multicenter, Open-label Study of Ifinatamab Deruxtecan (I-DXd), a B7-H3 Antibody-Drug Conjugate (ADC), in Combination With Atezolizumab With or Without Carboplatin as First-line Induction or Maintenance, in Subjects With Extensive-stage Small Cell Lung Cancer (ES-SCLC) (IDeate-Lung03)

A Study of I-DXd in Combination With Atezolizumab With or Without Carboplatin as First-Line Induction or Maintenance in Subjects With Extensive Stage-Small Cell Lung Cancer (IDeate-Lung03)

Condition
Extensive Stage-small Cell Lung Cancer
Intervention / Treatment

-

Contacts and Locations

Birmingham

University of Alabama -Birmingham, Birmingham, Alabama, United States, 35233

Los Angeles

David Geffen School of Medicine, Los Angeles, California, United States, 90095

Newport Beach

Hoag Memorial Hospital Presbyterian, Newport Beach, California, United States, 92663

Jacksonville

Mayo Clinic-Jacksonville, Jacksonville, Florida, United States, 32224

Orlando

Adventhealth Orlando, Orlando, Florida, United States, 32804

Chicago

Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, United States, 60611

Detroit

Henry Ford Hospital, Detroit, Michigan, United States, 48202

Minneapolis

Regents of the University of Minnesota, Minneapolis, Minnesota, United States, 55455

Rochester

Mayo Clinic, Rochester, Minnesota, United States, 55905

Lebanon

Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, United States, 03766

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

    Ages Eligible for Study

    18 Years to

    Sexes Eligible for Study

    ALL

    Accepts Healthy Volunteers

    No

    Collaborators and Investigators

    Daiichi Sankyo,

    Global Clinical Leader, STUDY_DIRECTOR, Daiichi Sankyo

    Study Record Dates

    2026-12-30