Diluted Aqueous Povidone-Iodine Compared to Saline to Decrease Surgical Site Infections

Description

This is a multicenter randomized controlled trial of 1100 patients to evaluate the superiority of combined intraoperative wound irrigation with intraoperative peritoneal lavage with dilute aqueous povidone-iodine compared to normal saline in male and female patients between the ages of 18 and 80 years old undergoing emergency laparotomies with Centers for Disease Control (CDC) class 2 and 3 wounds.

Conditions

Surgical Site Infection

Study Overview

Study Details

Study overview

This is a multicenter randomized controlled trial of 1100 patients to evaluate the superiority of combined intraoperative wound irrigation with intraoperative peritoneal lavage with dilute aqueous povidone-iodine compared to normal saline in male and female patients between the ages of 18 and 80 years old undergoing emergency laparotomies with Centers for Disease Control (CDC) class 2 and 3 wounds.

Wound Irrigation and Peritoneal Lavage With Diluted Aqueous Povidone-Iodine Compared to Saline to Decrease Surgical Site Infections

Diluted Aqueous Povidone-Iodine Compared to Saline to Decrease Surgical Site Infections

Condition
Surgical Site Infection
Intervention / Treatment

-

Contacts and Locations

Loma Linda

Loma Linda University Health, Loma Linda, California, United States, 92354

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * 18 to 80 years of age
  • * undergoing an exploratory laparotomy for Centers for Disease Control class II and III wounds
  • * Pregnancy
  • * Preoperative abdominal wall skin/soft tissue infection
  • * Iodine allergy
  • * Patients unlikely to survive beyond 30 days
  • * Patients with mesh placement or placement of a foreign body except for drains

Ages Eligible for Study

18 Years to 80 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Loma Linda University,

Study Record Dates

2025-11