Dry Mouth Toothpaste Study - Comparing Two Toothpastes With Arginine

Eligibility Criteria

• 1. Male or female volunteers 18- 80 years of age and in general good health.
• 2. Willing and able to understand and sign the informed consent form.
• 3. Subjects currently taking at least two medications known to cause xerostomia (dry mouth) as a side effect for the last three months.
• 4. Be willing to conform to the study protocol and procedures.
• 5. Polypharmacy subjects must score 4 or more on the VAS scale of 0-10 ("How severe is your dryness right now?").
• 6. Flow of 5 minutes unstimulated saliva should be below 0.16 ml/min.
• 7. No known history of allergy to personal care/consumer products or their ingredients, relevant to any ingredients in the test products as determined by the study examiner.
• 8. Minimum of 10 teeth
• 1. Subjects unable to understand or unwilling to sign the informed consent form.
• 2. Medical condition which requires premedication prior to dental visits/procedure.
• 3. Active disease of the hard or soft oral tissues.
• 4. History of salivary gland disease such as Sjogren's syndrome, Sarcoidosis, or Head and Neck Radiation Therapy.
• 5. Use of antibiotics or antimicrobial drugs within 30 days prior to study start.
• 6. Participation in any other clinical study within 1 week prior to enrollment into this study.
• 7. Subjects who must receive dental treatment during the study dates.
• 8. Immunocompromised individuals (HIV, AIDS, immunosuppressive drug therapy).
• 9. Presence of orthodontic bands.
• 10. Current smokers (if former smoker, should have stopped at least 1 month prior to Visit 1)
• 11. Use of pilocarpine or other cholinergic stimulating receptor actives prescribed after study enrollment or whose medication dose increases (stable dose for 3 months).
• 12. People on hormone therapy
• 13. Pregnant or lactating subjects.
• 14. Medical condition which prohibits not eating/drinking or chewing gum for four (4) hours prior to your scheduled visits;
• 15. Subjects who have an infectious disease and/or other blood borne diseases (Hepatitis series, HIV, tuberculosis).