Screening for AL Amyloidosis in Smoldering Multiple Myeloma

Description

In this multicenter study, we will recruit 400 patients 40 years of age or older at 15 centers with a diagnosis of smoldering multiple myeloma (SMM), a group of patients for whom standard of care is observation not treatment. The main goal of this study is to screen for the diagnosis of light-chain amyloidosis (AL) before the onset of symptomatic disease and to develop a training set for a likelihood algorithm.

Conditions

Smoldering Multiple Myeloma

Study Overview

Study Details

Study overview

In this multicenter study, we will recruit 400 patients 40 years of age or older at 15 centers with a diagnosis of smoldering multiple myeloma (SMM), a group of patients for whom standard of care is observation not treatment. The main goal of this study is to screen for the diagnosis of light-chain amyloidosis (AL) before the onset of symptomatic disease and to develop a training set for a likelihood algorithm.

Screening for AL Amyloidosis in Smoldering Multiple Myeloma

Screening for AL Amyloidosis in Smoldering Multiple Myeloma

Condition
Smoldering Multiple Myeloma
Intervention / Treatment

-

Contacts and Locations

Birmingham

University of Alabama Hospital, Birmingham, Alabama, United States, 35233

Los Angeles

Cedars-Sinai Medical Center, Los Angeles, California, United States, 90048

Orange

University of California, Irvine, Orange, California, United States, 92868

San Francisco

University of California, San Francisco, San Francisco, California, United States, 94143

Weston

Cleveland Clinic Florida, Weston Hospital, Weston, Florida, United States, 33331

Boston

Tufts Medical Center, Boston, Massachusetts, United States, 02111

New York

Columbia University Irving Medical Center, New York, New York, United States, 10032

New York

Memorial Sloan Kettering Cancer Center, New York, New York, United States, 10065

Charlotte

Atrium Health Levine Cancer Institute, Charlotte, North Carolina, United States, 28204

Durham

UNC Lineberger Comprehensive Cancer Center, Durham, North Carolina, United States, 27705

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Patients 40 years of age and older
  • * diagnosed with Smoldering Multiple Myeloma
  • * dFLC greater than 23 mg/L
  • * abnormal FLC ratio
  • * If the patient has an eGFR less than 50 mL/min/1.73m2, the FLC ratio is inconsequential. The patient only needs to meet the age and dFLC criterion.
  • * Patients younger than 40 years of age are not eligible
  • * Patients with a previous finding of amyloid in other biopsies will not be included
  • * Adults unable to consent are not eligible, including the cognitively impaired Pregnant women, pregnant minors, minors (i.e., individuals who are not yet adults), wards of the state, non-viable neonates, neonates of uncertain viability, and prisoners are not eligible

Ages Eligible for Study

40 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Tufts Medical Center,

Study Record Dates

2029-02-27