The Acute T-Rex (Timing of Resistance Exercise) Study

Description

The primary aim of this study is to evaluate if a single bout of AM vs PM resistance exercise has different effects on insulin sensitivity and sleep. A randomized cross-over trial be used to compare resistance exercise at two different times of the day. Each condition will take place in a laboratory setting. Each condition will consist of exercise, overnight sleep, and oral glucose tolerance tests the following day. The AM exercise will occur \~1.5 hours after habitual wake, and PM exercise will occur \~11 hours after habitual wake. After a 2-6 week washout, participants will complete the other condition. The hypothesis is that PM exercise will be more beneficial than AM exercise in improving insulin sensitivity. This study could identify if there is a better time of day to perform resistance exercise to decrease risk of developing Type 2 Diabetes Mellitus.

Conditions

Diabetes Mellitus, Type 2, Insulin Resistance, Glucose Intolerance, Sleep Disturbance, Overweight or Obesity, Insulin Sensitivity

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Study Details

Study overview

The primary aim of this study is to evaluate if a single bout of AM vs PM resistance exercise has different effects on insulin sensitivity and sleep. A randomized cross-over trial be used to compare resistance exercise at two different times of the day. Each condition will take place in a laboratory setting. Each condition will consist of exercise, overnight sleep, and oral glucose tolerance tests the following day. The AM exercise will occur \~1.5 hours after habitual wake, and PM exercise will occur \~11 hours after habitual wake. After a 2-6 week washout, participants will complete the other condition. The hypothesis is that PM exercise will be more beneficial than AM exercise in improving insulin sensitivity. This study could identify if there is a better time of day to perform resistance exercise to decrease risk of developing Type 2 Diabetes Mellitus.

Timing (AM v PM) of Acute Resistance Exercise on Glycemic Control in Older Adults: The Acute T-Rex Study

The Acute T-Rex (Timing of Resistance Exercise) Study

Condition
Diabetes Mellitus, Type 2
Intervention / Treatment

-

Contacts and Locations

Salt Lake City

University of Utah HPER E Buildling, Salt Lake City, Utah, United States, 84112

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Men and women, all ethnicities, 50-74 years; BMI ≥25 kg/m2 to \<45 kg/m2; weight stable (\<5% change in past 6 months); and generally healthy, and who are not meeting recommended activity guidelines for aerobic or resistance exercise.
  • * Uncontrolled cardiovascular, metabolic, renal, or pulmonary disease; cancer treatment in the past 5 years; untreated thyroid disease or other medical condition affecting weight or energy metabolism; current use of weight loss medication or other medications highly likely to impact energy balance; bariatric surgery or extensive bowel resection in past 2 years; current or recent history (past 2 years) of eating disorder; Diagnosis of insomnia, sleep apnea, or other sleep and circadian disorders; non-english speaking. HbA1c \>6.5%

Ages Eligible for Study

50 Years to 74 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Utah,

Study Record Dates

2024-12-31