Intravenous Iron Versus Oral Iron for the Treatment of Iron Deficiency Anemia

Description

This study aims to assess whether administering intravenous iron early in pregnancy, compared to standard oral iron treatment, can enhance hemoglobin levels before delivery and reduce the need for blood transfusions in patients with iron deficiency anemia. Patients diagnosed with iron deficiency anemia were randomly assigned to receive either oral or intravenous iron. Before treatment initiation, patients completed a symptom questionnaire baseline hemoglobin, and ferritin levels were measured. Follow-up visits occurred four weeks later and at 24 to 28 weeks gestation, involving reassessment of symptoms, laboratory testing, and monitoring of treatment adherence. Final hemoglobin levels were determined before delivery, and data on the need for blood transfusion at delivery were recorded.

Conditions

Iron Deficiency Anemia of Pregnancy

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Study Overview

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Study Details

Study overview

This study aims to assess whether administering intravenous iron early in pregnancy, compared to standard oral iron treatment, can enhance hemoglobin levels before delivery and reduce the need for blood transfusions in patients with iron deficiency anemia. Patients diagnosed with iron deficiency anemia were randomly assigned to receive either oral or intravenous iron. Before treatment initiation, patients completed a symptom questionnaire baseline hemoglobin, and ferritin levels were measured. Follow-up visits occurred four weeks later and at 24 to 28 weeks gestation, involving reassessment of symptoms, laboratory testing, and monitoring of treatment adherence. Final hemoglobin levels were determined before delivery, and data on the need for blood transfusion at delivery were recorded.

Randomized Control Trial: Intravenous Iron Versus Oral Iron for the Treatment of Iron Deficiency Anemia in Pregnancy

Intravenous Iron Versus Oral Iron for the Treatment of Iron Deficiency Anemia

Condition
Iron Deficiency Anemia of Pregnancy
Intervention / Treatment

-

Contacts and Locations

Colton

Arrowhead Regional Medical Center, Colton, California, United States, 92324

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age \> 18 years of age
  • * Ferritin level \< 30 ng/mL
  • * Singe gestation
  • * Gestational age up to 36 weeks as iron therapy after this has shown to be not beneficial at time of delivery. We will still plan to treat patients \> 36 weeks but not include them in the final analysis
  • * Plan to delivery at Arrowhead Regional Medical Center (ARMC)
  • * Maternal age \< 18 years of age
  • * Incarcerated patients
  • * Multifetal gestation
  • * Acute liver/kidney disease
  • * Active infections
  • * Known hematological malignancy
  • * Other causes of anemia such as alpha/beta thalassemia, sickle cell disease, Folate/B12 deficiency, and anemia of chronic diseases
  • * Known hypersensitivity with IV iron
  • * Severe symptoms of anemia requiring blood transfusion

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Arrowhead Regional Medical Center,

Study Record Dates

2025-12-30