Monetary Incentive Delay Task for Probing Reward-related Neural Processes

Description

150 males and 150 females ages 14-17 years-old will be enrolled in an observational, longitudinal study. There are three planned in-person visits: a baseline assessment, an 18-month follow-up, and a 36-month follow-up. The in-person visits will include assessment of substance use and other individual differences (e.g., reward function, psychiatric history), neuromelanin-sensitive MRI, as well as functional brain activation collected while the participant is at rest (resting-state fMRI) and while the participant completes a Monetary Incentive Delay task. Subjects will also be asked to complete past 90-day substance use assessments remotely every 90 days for 36 months.

Conditions

Adolescent Development

Study Overview

Study Details

Study overview

150 males and 150 females ages 14-17 years-old will be enrolled in an observational, longitudinal study. There are three planned in-person visits: a baseline assessment, an 18-month follow-up, and a 36-month follow-up. The in-person visits will include assessment of substance use and other individual differences (e.g., reward function, psychiatric history), neuromelanin-sensitive MRI, as well as functional brain activation collected while the participant is at rest (resting-state fMRI) and while the participant completes a Monetary Incentive Delay task. Subjects will also be asked to complete past 90-day substance use assessments remotely every 90 days for 36 months.

Neuromelanin MRI: A Tool for Non-invasive Investigation of Dopaminergic Abnormalities in Adolescent Substance Use

Monetary Incentive Delay Task for Probing Reward-related Neural Processes

Condition
Adolescent Development
Intervention / Treatment

-

Contacts and Locations

Stony Brook

Stony Brook Medicine, Stony Brook, New York, United States, 11794

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * (A) Males and females ages 14-17 years-old; (B) English-speaking for assent and interview completion, and (C) capacity to provide assent. For parents, the inclusion criteria will be (D) willing and capacity to provide parental permission/consent.
  • * (A) current (within 6 months) use of medication that may affect cerebral function; (B) history of severe medical or neurological illness, including stroke or seizure; (C) history of head trauma with loss of consciousness; (D) presence of metal in the body; (E) pregnancy or breastfeeding; (F) recent drug or alcohol use determined by positive urine toxicology or breathalyzer (to validate self-report assessment of substance use history); (G) lifetime use of psychotropic or other medication that could likely influence dopamine function, namely stimulant medication or antipsychotic medication.

Ages Eligible for Study

14 Years to 17 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Stony Brook University,

Study Record Dates

2028-11-30