Burn Study- Tranexamic Acid Versus Thrombin in Split Thickness Skin Graft

Description

Investigators hypothesize that topical tranexamic acid will have better or comparable efficacy to topical thrombin in reducing hematoma formation at the wound base. The purpose of the study is to demonstrate that topical tranexamic acid will be a non-inferior alternative medication to the current standard of care,THROMBIN-JMI® , and at a lower cost to the health system.

Conditions

Burns, Skin Graft Complications

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Study Overview

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Study Details

Study overview

Investigators hypothesize that topical tranexamic acid will have better or comparable efficacy to topical thrombin in reducing hematoma formation at the wound base. The purpose of the study is to demonstrate that topical tranexamic acid will be a non-inferior alternative medication to the current standard of care,THROMBIN-JMI® , and at a lower cost to the health system.

The Use of Topical Tranexamic Acid Versus Thrombin Spray for the Management of Split Thickness Skin Graft Recipient Site in Burn Management

Burn Study- Tranexamic Acid Versus Thrombin in Split Thickness Skin Graft

Condition
Burns
Intervention / Treatment

-

Contacts and Locations

Kansas City

The University of Kansas Health System, Kansas City, Kansas, United States, 66160

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * English or Spanish speaking
  • * Flame or scald burn injury
  • * \<=10% total body surface area (TBSA) partial thickness
  • * \<= 5% total body surface area (TBSA) deep partial or full thickness
  • * Skin graft harvested at 1/12 inch depth, meshed 1:1 or pie crusted if the area is a small functional area
  • * \>10% total body surface area (TBSA) partial thickness burn
  • * \>5% total body surface area (TBSA )surgical area of burn injury (deep partial or full thickness injury)
  • * Traumatic or chemical burn mechanism
  • * Patients on immunosuppression
  • * Uncontrolled diabetes
  • * Known diagnosis of peripheral vascular disease or diagnosis at time of injury
  • * Pregnant women
  • * Patients with acquired defective color vision
  • * Patients with subarachnoid hemorrhage
  • * Patients with active intravascular clotting or known hypersensitivity reactions to tranexamic acid
  • * Inability to give informed consent

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Kansas Medical Center,

Dhaval Bhavsar, MBBS, PRINCIPAL_INVESTIGATOR, The University of Kansas Medical Center

Study Record Dates

2026-12