COMPLETED

Detecting Lymph Node Metastasis in Intrahepatic Cholangiocarcinoma (LyMIC)

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Lymph node metastasis (LNM) is a major prognostic factor in intrahepatic cholangiocarcinoma (ICC), and accurate preoperative prediction of the presence or absence of LNM has significant clinical implications in determining treatment strategy. Despite this, there are currently no reliable biomarkers established to detect LNM in ICC. This study seeks to develop a liquid biopsy assay that can accurately detect LNM before treatment in ICC patients.

Official Title

An Exosome-based Liquid Biopsy Signature for Pre-operative Identification of Lymph Node Metastasis in Patients With Intrahepatic Cholangiocarcinoma

Quick Facts

Study Start:2023-04-15
Study Completion:2025-07-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:COMPLETED

Study ID

NCT06381648

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * A histologically confirmed diagnosis of intrahepatic cholangiocarcinoma.
  2. * Received standard diagnostic and staging procedures as per local guidelines
  3. * Availability of at least one blood-derived sample, drawn before receiving any curative-intent treatment
  1. * Lack of or inability to provide informed consent
  2. * Synchronous Intrahepatic cholangiocarcinoma and non- Intrahepatic cholangiocarcinoma diagnosed at or before surgery
  3. * Secondary liver cancer

Contacts and Locations

Principal Investigator

Ajay Goel, PhD
PRINCIPAL_INVESTIGATOR
City of Hope Medical Center

Study Locations (Sites)

City of Hope Medical Center
Duarte, California, 91016
United States

Collaborators and Investigators

Sponsor: City of Hope Medical Center

  • Ajay Goel, PhD, PRINCIPAL_INVESTIGATOR, City of Hope Medical Center

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-04-15
Study Completion Date2025-07-01

Study Record Updates

Study Start Date2023-04-15
Study Completion Date2025-07-01

Terms related to this study

Keywords Provided by Researchers

  • Intrahepatic cholangiocarcinoma
  • Exosome
  • micro-RNA
  • Liquid biopsy
  • Blood test
  • Lymph node metastasis
  • Lymph node dissection
  • Lymphadenectomy

Additional Relevant MeSH Terms

  • Cholangiocarcinoma
  • Cholangiocarcinoma, Intrahepatic
  • Cholangiocarcinoma Resectable
  • Cholangiocarcinoma; Liver