Assessing the Impact of Botulinum Toxin Type A on Facial Wrinkles: A Comprehensive Clinical Investigation

Eligibility Criteria

• * Individuals of both genders.
• * Must be in good physical health.
• * Age between 20 and 65 years.
• * Presence of both static (unchanging) and moderate dynamic (movement-induced) wrinkles on the forehead or glabellar region.
• * Must possess the willingness and ability to understand and provide informed consent, as well as effectively communicate with study personnel.
• * Pregnant or breastfeeding female.
• * Age below 20 or above 65 years.
• * History of neuromuscular disorders, such as myasthenia gravis.
• * History of facial surgery or presence of scars in the treatment area that could potentially interfere with or confound the results of the study.
• * Recent treatment history within the past 6 months in the forehead or glabellar region, including:
• * Ablative laser procedures.
• * Radiofrequency device treatments.
• * Ultrasound device treatments.
• * Medium to deep chemical peels.
• * Temporary soft tissue augmentation.
• * Semi-permanent soft tissue augmentation within the past 2 years.
• * Permanent soft tissue augmentation.
• * Planned cosmetic procedures within the next 6 months in the same region.
• * Intended use of tretinoin or retinoic acid within the next 6 months.
• * Presence of active infection in the treated area, excluding mild acne.
• * Allergy to cow's milk protein or albumin.
• * Use of aminoglycoside medications.
• * Current use of anticoagulation therapy.
• * History of bleeding disorders.
• * Diagnosis of mental illness.
• * Inability to comprehend the study protocol or provide informed consent.