RECRUITING

Personalized GI Motility Responses to Diet

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this randomized, crossover, clinical trial is to link: 1) gastrointestinal motility patterns induced by acute consumption of whole and refined grains, 2) enteric microbial production of bioactive metabolites, and 3) circulating postprandial appearance of metabolites important to cardiometabolic health including glucose, triglycerides, and cholesterol. Participants will be asked to consume a Smartpill monitoring device that records metrics of gastrointestinal motility in response to whole or refined grains, monitor cardiometabolic metabolties over an 8 hour postprandial window, and provide a fecal sample for microbiome-related analyses.

Official Title

Personalized Gastrointestinal Motility Responses to Dietary Fiber and Gut Microbial Metabolites

Quick Facts

Study Start:2024-03-07
Study Completion:2025-06-02
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06386471

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:21 Years to 63 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * Healthy men and women
  1. * Diabetes Mellitus
  2. * Nutrient-malabsorption disorders
  3. * Intestinal Bowel Syndrome (IBS)
  4. * Intestinal Bowel Disease (IBD)
  5. * Bleeding-related disorders
  6. * Grain allergy
  7. * Psychological Disorders
  8. * Stenosis
  9. * Dysphasia
  10. * Bariatric Surgery
  11. * Gallbladder removal
  12. * Eating disorders
  13. * Antibiotic administration (within the past three months)
  14. * Hormone therapy
  15. * Using statins
  16. * Pregnant, lactating, or postmenopausal
  17. * Taking oral hypoglycemic agents or insulin
  18. * Ingesting prescription fiber
  19. * Using cholesterol and bile acid absorption inhibitors
  20. * Ingesting nutrition supplements, not including a daily multivitamin (i.e. herbs, tinctures, and extracts) •Using recreational drugs or alcohol (within the past week)
  21. * Taking anti-histamines
  22. * Taking proton pump inhibitors
  23. * Taking antacids

Contacts and Locations

Study Contact

Brett R Loman, PhD, RD
CONTACT
217-333-3451
bloman2@illinois.edu

Study Locations (Sites)

University of Illinois at Urbana-Champaign
Urbana, Illinois, 61801
United States

Collaborators and Investigators

Sponsor: University of Illinois at Urbana-Champaign

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-03-07
Study Completion Date2025-06-02

Study Record Updates

Study Start Date2024-03-07
Study Completion Date2025-06-02

Terms related to this study

Keywords Provided by Researchers

  • dietary fiber
  • gastrointestinal motility
  • cardiometabolic
  • microbiome

Additional Relevant MeSH Terms

  • Nutritional and Metabolic Diseases
  • Gastrointestinal Dysfunction
  • Cardiovascular Diseases
  • Dysbiosis