Low Systemic/High Local Exercise Load in Peds SCD

Description

This research study wants to learn about what kind of exercise is best for kids with sickle cell disease. Participating children will have a small amount of blood drawn one time at the beginning of the study. Children will then complete some questionnaires that measure pain, physical function, and emotions (depression, anxiety) and complete some tests that measure physical fitness at the beginning and end of the study. Children will be randomized to either a home-based telehealth (1) walking or (2) strengthening exercise program that lasts for 8-weeks, 3-x week, for 45 minutes each session. Children's participation will last up to 10 weeks.

Conditions

Sickle Cell Anemia in Children

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Study Overview

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Study Details

Study overview

This research study wants to learn about what kind of exercise is best for kids with sickle cell disease. Participating children will have a small amount of blood drawn one time at the beginning of the study. Children will then complete some questionnaires that measure pain, physical function, and emotions (depression, anxiety) and complete some tests that measure physical fitness at the beginning and end of the study. Children will be randomized to either a home-based telehealth (1) walking or (2) strengthening exercise program that lasts for 8-weeks, 3-x week, for 45 minutes each session. Children's participation will last up to 10 weeks.

Low Systemic/High Local Exercise Load in Pediatric Sickle Cell Disease

Low Systemic/High Local Exercise Load in Peds SCD

Condition
Sickle Cell Anemia in Children
Intervention / Treatment

-

Contacts and Locations

Jackson

University of Mississippi Medical Center, Jackson, Mississippi, United States, 39216

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * youth 12 to 17 years old
  • * diagnosed with SCD genotype SS, SC, beta-plus thalassemia, or beta-zero thalassemia
  • * has daily access to an Internet enabled device (e.g., smart phone, IPad) A parent (≥21 years old) will also be recruited for each youth participant.
  • * non-English speaking due to lack of available written translation services for informed consent and questionnaires
  • * cognitive impairment (e.g., moderate to profound intellectual disability) that precludes study completion
  • * medical condition (e.g., hypertension, bone fracture) that precludes completing exercise safely (determined by study medical director Dr. McNaull).

Ages Eligible for Study

12 Years to 17 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Mississippi Medical Center,

Yolanda Griffin, STUDY_DIRECTOR, Director-Clinical Trials Office

Study Record Dates

2025-06-30