Understanding and Preventing Cortical Mechanisms of Chemotherapy-induced Peripheral Neuropathy

Eligibility Criteria

• 1. Participants must have the ability to understand and read English, sign a written informed consent, and be willing to follow protocol requirements.
• 2. ECOG Performance Status of 0-2;
• 3. Willing to come to MD Anderson for the imaging sessions.
• 4. Are 18 years of age or above.
• 5. Have a diagnosis of breast cancer and who are scheduled to begin chemotherapy.
• 6. will receive chemotherapy including doxorubicin, cyclophosphamide, docetaxel, or paclitaxel; 7) participants scheduled to receive six months of chemotherapy.
• 1. Participants who are taking any antipsychotic medications.
• 2. With active CNS disease, such as clinically evident metastases or leptomeningeal disease, dementia, or encephalopathy.
• 3. Have ever been diagnosed with bipolar disorder or schizophrenia.
• 4. Known, previously diagnosed peripheral neuropathy from causes other than chemotherapy; and
• 5. A history of head injury or who have known seizure activity, or with a prior history of chemotherapy.
• 6. Patients who will be administered ddAC-\>T.